MK-8666

DB14937InvestigationalSmall molecule

MK-8666 is under investigation in clinical trial NCT01971554 (Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of MK-8666 in Participants With Type 2 Diabetes Mellitus (MK-8666-003)).

Mechanism: Pharmacologically active on Free fatty acid receptor 1
Curator reviewed
Formula / weight: C₂₉H₃₁NO₆S · 521.63 g/mol (avg)
Code names: MK-8666

Resolves to

Compound

UNII11612L5SPICAS1544739-75-4

Structure

InChIKeyCODQKEMYZZKQAE-QPVYNBJUSA-NSMILESCC1=CC(OCCCS(C)(=O)=O)=CC(C)=C1C1=CC(COC2=CC3=C(C=N2)[C@H]2[C@@H](C3)[C@@H]2C(O)=O)=CC=C1

Targets

O14842FFAR1

What you can answer from here — as of July 07, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with MK-8666, and which of those have an active Phase 3 trial?

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