Lanosterol 14-alpha demethylase

BE0000690ProteinERG11

Sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (By similarity). It is acted on by 4 drugs in DrugBank.

Gene name
ERG11
UniProtKB entry
P50859Swiss-Prot
Cellular location
Membrane
Residues / weight
533 residues · 61,305 Da
Also known as
1.14.13.70 · 1.14.14.154 · CYP51 · CYPLI · Cytochrome P450 51

Resolves to

Protein
UniProtP50859UniProt nameCP51_CANGA
Gene
NCBI Gene2887532GenBank755693
Pharmacology
KEGGcgr:CAGL0E04334g
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lanosterol 14-alpha demethylase, how selective are they, and which programs against it are still in active trials?

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