Sulconazole is a topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains. Sulconazole, brand name Exelderm, is a broad-spectrum anti-fungal agent available as a topical cream and solution.
- Mechanism
- Curator reviewed · 3 references
The mechanism of action of sulconazole is not well established; however, it is thought to be similar to other imidazole derivatives. The function of imidazoles can be attributed to their structural resemblance to purines essential to metabolism. Imidazoles inhibit lanosterol 14-alpha demethylase, a cytochrome P-450-dependent enzyme in fungi responsible for converting lanosterol to ergosterol. Since ergosterol is required to maintain the integrity of the fungi membrane, the inhibition of lanosterol 14-alpha demethylase leads to increased fungal cellular permeability. Therefore, the use of an imidazole such as sulconazole inhibits fungal growth.
- Primary indication
- Sulconazole solution 1.0% is indicated for the treatment of tinea cruris and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis; and for the treatment of tinea versicolor.Curator reviewed · 4 structured indications
- Formula / weight
- C18H15Cl3N2S · 397.74 g/mol (avg)
- First approval
- United States, 1989
- Code names
- RS-44872
- Brand names
Resolves to
AFNXATANNDIXLG-UHFFFAOYSA-NSMILESClC1=CC=C(CSC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=C1What you can answer from here — as of September 13, 2026
Which drugs share a target with Sulconazole, and which of those have an active Phase 3 trial?
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