High affinity choline transporter 1

BE0000696ProteinHumansSLC5A7

High-affinity Na(+)-coupled choline transmembrane symporter (PubMed:11027560, PubMed:11068039, PubMed:12237312, PubMed:12969261, PubMed:17005849, PubMed:23132865, PubMed:23141292, PubMed:27569547, PubMed:40972734). It is acted on by 3 drugs in DrugBank.

Gene name
SLC5A7
UniProtKB entry
Q9GZV3Swiss-Prot
Cellular location
Presynaptic cell membrane
Residues / weight
580 residues · 63,203 Da
Also known as
CHT · CHT1 · hCHT1 · Hemicholinium-3-sensitive choline transporter · Solute carrier family 5 member 7

Resolves to

Protein
UniProtQ9GZV3UniProt nameSC5A7_HUMAN
Gene
HGNCHGNC:14025NCBI Gene60482GenBank10998442GeneCardsSLC5A7
Pharmacology
IUPHAR/GtoPdb914KEGGhsa:60482
Structure
PDB8J74PDB8J75PDB8J76
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on High affinity choline transporter 1, how selective are they, and which programs against it are still in active trials?

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