Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

BE0000727ProteinHumansAADAT

Transaminase with broad substrate specificity. It is acted on by 3 drugs in DrugBank.

Gene name
AADAT
UniProtKB entry
Q8N5Z0Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
425 residues · 47,351 Da
Also known as
2-aminoadipate aminotransferase · 2-aminoadipate transaminase · AadAT · Alpha-aminoadipate aminotransferase · Glycine transaminase AADAT

Resolves to

Protein
UniProtQ8N5Z0UniProt nameAADAT_HUMAN
Gene
HGNCHGNC:17929NCBI Gene51166GenBank6165634GeneCardsAADAT
Pharmacology
KEGGhsa:51166
Structure
PDB2QLRPDB2R2NPDB2VGZ
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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