NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

BE0000729ProteinHumansNDUFS2

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:22036843, PubMed:28031252, PubMed:30922174). It is acted on by 3 drugs in DrugBank.

Gene name
NDUFS2
UniProtKB entry
O75306Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
463 residues · 52,545 Da
Also known as
7.1.1.2 · CI-49kD · Complex I-49kD · NADH-ubiquinone oxidoreductase 49 kDa subunit

Resolves to

Protein
UniProtO75306UniProt nameNDUS2_HUMAN
Gene
HGNCHGNC:7708NCBI Gene4720GenBank3540239GeneCardsNDUFS2
Pharmacology
KEGGhsa:4720
Structure
PDB5XTBPDB5XTCPDB5XTD
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial, how selective are they, and which programs against it are still in active trials?

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