Biliverdin reductase A

BE0000741ProteinHumansBLVRA

Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). It is acted on by 3 drugs in DrugBank.

Gene name
BLVRA
UniProtKB entry
P53004Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
296 residues · 33,428 Da
Also known as
1.3.1.24 · Biliverdin-IX alpha-reductase · BLVR · BVR · BVR A

Resolves to

Protein
UniProtP53004UniProt nameBIEA_HUMAN
Gene
HGNCHGNC:1062NCBI Gene644GenBank1246749GeneCardsBLVRA
Pharmacology
KEGGhsa:644
Structure
PDB2H63
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Biliverdin reductase A, how selective are they, and which programs against it are still in active trials?

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