Nadide
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Nadide
- DrugBank Accession Number
- DB14128
- Background
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 663.4251
Monoisotopic: 663.109121631 - Chemical Formula
- C21H27N7O14P2
- Synonyms
- beta-Diphosphopyridine nucleotide
- beta-NAD
- beta-NAD+
- beta-Nicotinamide adenine dinucleotide
- Codehydrase I
- Codehydrogenase I
- Coenzyme I
- Cozymase I
- Diphosphopyridine nucleotide
- DPN
- NAD
- NAD+
- Nadida
- Nadide
- Nadidum
- Nicotinamide adenine dinucleotide
- Nicotinamide dinucleotide
- Nicotinamide-adenine dinucleotide
- Nicotineamide adenine dinucleotide
- Oxidized diphosphopyridine nucleotide
- Pyridine, nucleotide diphosphate
- External IDs
- BRN 3584133
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Bonogen hair care shampoo Nadide (0.3 g/100g) + Biotin (0.06 g/100g) + Panthenol (0.5 g/100g) + Pyrithione zinc (2.1 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-03-01 Not applicable US Bonogen Plus hair care shampoo Nadide (0.3 g/100g) + Biotin (0.06 g/100g) + Panthenol (0.6 g/100g) + Pyrithione zinc (2.1 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-04-09 Not applicable US Born Hair Nadide (0.3 g/100g) + Biotin (0.06 g/100g) + Panthenol (0.6 g/100g) + Pyrithione zinc (2.1 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-04-09 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Bonogen hair care shampoo Nadide (0.3 g/100g) + Biotin (0.06 g/100g) + Panthenol (0.5 g/100g) + Pyrithione zinc (2.1 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-03-01 Not applicable US Bonogen Plus hair care shampoo Nadide (0.3 g/100g) + Biotin (0.06 g/100g) + Panthenol (0.6 g/100g) + Pyrithione zinc (2.1 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-04-09 Not applicable US Born Hair Nadide (0.3 g/100g) + Biotin (0.06 g/100g) + Panthenol (0.6 g/100g) + Pyrithione zinc (2.1 g/100g) Shampoo Topical Bonogen Co., Ltd 2010-04-09 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as (5'->5')-dinucleotides. These are dinucleotides where the two bases are connected via a (5'->5')-phosphodiester linkage.
- Kingdom
- Organic compounds
- Super Class
- Nucleosides, nucleotides, and analogues
- Class
- (5'->5')-dinucleotides
- Sub Class
- Not Available
- Direct Parent
- (5'->5')-dinucleotides
- Alternative Parents
- Purine nucleotide sugars / Purine ribonucleoside diphosphates / Purine ribonucleoside monophosphates / Nicotinamide nucleotides / Pentose phosphates / Glycosylamines / Monosaccharide phosphates / 6-aminopurines / Organic pyrophosphates / Nicotinamides show 16 more
- Substituents
- (5'->5')-dinucleotide / 6-aminopurine / Alcohol / Alkyl phosphate / Amine / Aminopyrimidine / Aromatic heteropolycyclic compound / Azacycle / Azole / Carboximidic acid show 39 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- NAD (CHEBI:44215)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 0U46U6E8UK
- CAS number
- 53-84-9
- InChI Key
- BAWFJGJZGIEFAR-NNYOXOHSSA-N
- InChI
- InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
- IUPAC Name
- 1-[(2R,3R,4S,5R)-5-({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono}oxy)(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxyoxolan-2-yl]-3-(C-hydroxycarbonimidoyl)-1lambda5-pyridin-1-ylium
- SMILES
- NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
References
- General References
- Not Available
- External Links
- ChemSpider
- 5681
- BindingDB
- 213227
- 1044975
- ChEBI
- 44215
- ChEMBL
- CHEMBL1234613
- PDBe Ligand
- NAD
- Wikipedia
- Nicotinamide_adenine_dinucleotide
- PDB Entries
- 1a4z / 1a5z / 1a71 / 1a7a / 1a7k / 1a9y / 1a9z / 1ad3 / 1agn / 1ahh … show 1793 more
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Coronavirus Disease 2019 (COVID‑19) / Post COVID-19 Syndrome / Post-acute COVID-19 (PACS), or "Long COVID" Syndrome 1 0 Recruiting Treatment Sudden Sensorineural Hearing Loss (SSNHL) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Shampoo Topical - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 2.14 mg/mL ALOGPS logP -1.2 ALOGPS logP -11 Chemaxon logS -2.5 ALOGPS pKa (Strongest Acidic) 1.86 Chemaxon pKa (Strongest Basic) 6.4 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 16 Chemaxon Hydrogen Donor Count 8 Chemaxon Polar Surface Area 322.08 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 151.81 m3·mol-1 Chemaxon Polarizability 58.5 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at June 24, 2018 16:59 / Updated at February 21, 2021 18:54