ATPase GET3

BE0000750ProteinHumansGET3

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:17382883). It is acted on by 1 drug in DrugBank.

Gene name
GET3
UniProtKB entry
O43681Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
348 residues · 38,792 Da
Also known as
3.6.4.- · ARSA · Arsenical pump-driving ATPase · Arsenite-stimulated ATPase · ASNA1

Resolves to

Protein
UniProtO43681UniProt nameGET3_HUMAN
Gene
HGNCHGNC:752NCBI Gene439GenBank2905657GeneCardsGET3
Pharmacology
KEGGhsa:439
Structure
PDB6SO5PDB8CQZPDB8CR1
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on ATPase GET3, and which indications are they being tested in?

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