Sodium/hydrogen exchanger 1

BE0000752ProteinHumansSLC9A1

Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937,... It is acted on by 9 drugs in DrugBank.

Gene name
SLC9A1
UniProtKB entry
P19634Swiss-Prot
Cellular location
Cell membrane
Residues / weight
815 residues · 90,762 Da
Also known as
APNH · APNH1 · Na(+)/H(+) antiporter, amiloride-sensitive · Na(+)/H(+) exchanger 1 · NHE-1

Resolves to

Protein
UniProtP19634UniProt nameSL9A1_HUMAN
Gene
HGNCHGNC:11071NCBI Gene6548GenBank178753GeneCardsSLC9A1
Pharmacology
KEGGhsa:6548
Structure
PDB1Y4EPDB23XKPDB23XM
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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45GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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59+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/hydrogen exchanger 1, how selective are they, and which programs against it are still in active trials?

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