Leucine--tRNA ligase, cytoplasmic

BE0000769ProteinHumansLARS1

Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)) (PubMed:25051973, PubMed:32232361). It is acted on by 2 drugs in DrugBank.

Gene name
LARS1
UniProtKB entry
Q9P2J5Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,176 residues · 134,465 Da
Also known as
6.1.1.4 · cLRS · KIAA1352 · LARS · Leucyl-tRNA synthetase

Resolves to

Protein
UniProtQ9P2J5UniProt nameSYLC_HUMAN
Gene
HGNCHGNC:6512NCBI Gene51520GenBank7804450GeneCardsLARS1
Pharmacology
KEGGhsa:51520
Structure
PDB2WFDPDB6KIDPDB6KIE
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Leucine--tRNA ligase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

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