Malate dehydrogenase, mitochondrial

BE0000780ProteinHumansMDH2

Mitochondrial malate dehydrogenase that catalyzes the reversible conversion of malate to oxaloacetate using NAD(+) as a cofactor (PubMed:27989324). It is acted on by 4 drugs in DrugBank.

Gene name
MDH2
UniProtKB entry
P40926Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
338 residues · 35,503 Da
Also known as
1.1.1.37

Resolves to

Protein
UniProtP40926UniProt nameMDHM_HUMAN
Gene
HGNCHGNC:6971NCBI Gene4191GenBank2906146GeneCardsMDH2
Pharmacology
KEGGhsa:4191
Structure
PDB2DFDPDB4WLEPDB4WLF
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Malate dehydrogenase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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