Citric acid

DB04272ApprovedInvestigationalNutraceuticalVet approvedSmall moleculeCalculi Dissolution Agent

Citric acid is an anti-chelation additive used in blood collection tubes and as a flavoring and preservative agent in various cosmetic and pharmaceutical products. A key intermediate in metabolism.

Chemical structure of Citric acid
Mechanism
Curator reviewed
Formula / weight
C6H8O7 · 192.1235 g/mol (avg)
First approval
Canada, 1998 · United States, 1980
Also known as
Anhydrous citric acid · Citrate · Citric acid monoglyceride · Citric acid, anhydrous
Code names
FEMA NO. 2306 · NSC-112226 · NSC-30279 · NSC-626579
Brand names
  • Alka-seltzer
  • Alka-seltzer Fruit Chews
  • Alka-seltzer Heartburn Relief
  • As 3
  • Citrasate
  • Clenpiq
  • Cpda-1 Blood Collection System
  • Cytra-K
  • EnLyte
  • Hemosate Ultra
  • Leukotrap
  • Oracit
  • Phexx
  • Phexxi
  • Pico-salax
  • Purg-odan
  • Renacidin
  • +7 moreShow less

Resolves to

Compound
UNIIXF417D3PSLCAS77-92-9ChEMBLCHEMBL1261ChEBI30769PubChem88113319KEGGD00037
Clinical / RWD
RxNorm21183ATCA09AB04PharmGKBPA449021
Structure
InChIKeyKRKNYBCHXYNGOX-UHFFFAOYSA-NSMILESOC(=O)CC(O)(CC(O)=O)C(O)=O
Targets
C7C422blaNDM-1P15121AKR1B1P39126icdP00808penPP10613ERG11Q9HBA0TRPV4P04190blmO75390CS+43 more
Transporters
O94956SLCO2B1

What you can answer from here — as of September 23, 2026

52Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
1TransporterSubstrate / inhibitor direction, not just membership
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42Drug interactionsStructured to mechanism, not free text
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157Clinical trialsPhase, status and sponsor resolved per trial
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16Structured indicationsCondition, population, route and combination as fields, not prose
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496Marketed productsAcross 11 countries and 181 labellers
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1ATC codeIncluding every combination product, plus 19 drug categories
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27+ReferencesStructured and connected to the statements they support
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