Citric acid
Identification
- Name
- Citric acid
- Accession Number
- DB04272
- Description
A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
Citric acid was one of active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020.1
- Type
- Small Molecule
- Groups
- Approved, Nutraceutical, Vet approved
- Structure
Structure for Citric acid (DB04272)
- Weight
- Average: 192.1235
Monoisotopic: 192.02700261 - Chemical Formula
- C6H8O7
- Synonyms
- 2-hydroxy-1,2,3-propanetricarboxyic acid
- 2-Hydroxytricarballylic acid
- 3-carboxy-3-hydroxypentane-1,5-dioic acid
- ácido cítrico
- Acidum citricum
- Anhydrous citric acid
- Citric acid monoglyceride
- Citric Acid, Anhydrous
- Citric acid,anhydrous
- Citronensäure
- External IDs
- FEMA NO. 2306
- NSC-112226
- NSC-30279
- NSC-626579
Pharmacology
- Indication
- Not Available
- Associated Conditions
- Associated Therapies
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
- Not Available
- Mechanism of action
Target Actions Organism UFumarate hydratase class II inhibitorEscherichia coli (strain K12) U6-phosphogluconolactonase Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UL-amino-acid oxidase Not Available Humans UCarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Not Available Humans UCytochrome c peroxidase Not Available Marinobacter hydrocarbonoclasticus UHepatocyte growth factor-regulated tyrosine kinase substrate Not Available Humans UInvasin Not Available Yersinia pseudotuberculosis serotype I (strain IP32953) UIntron-associated endonuclease 1 Not Available Enterobacteria phage T4 UShort tail fiber protein Not Available Enterobacteria phage T4 UMalate dehydrogenase, mitochondrial Not Available Humans UN5-carboxyaminoimidazole ribonucleotide mutase Not Available Acetobacter aceti U50S ribosomal protein L4 Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UCarboxypeptidase B Not Available Humans UHexon protein Not Available HAdV-2 URiboflavin biosynthesis protein RibF Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UBeta-fructosidase Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UPutative stringent starvation protein A Not Available Yersinia pestis UCitrate synthase Not Available Thermus thermophilus URNA 3'-terminal phosphate cyclase Not Available Escherichia coli (strain K12) UU6 snRNA-associated Sm-like protein LSm6 Not Available Humans UPleckstrin homology domain-containing family A member 1 Not Available Humans UFe(3+)-binding periplasmic protein Not Available Serratia marcescens USignal recognition particle receptor FtsY Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UNicotinate-nucleotide adenylyltransferase Not Available Shigella flexneri UN utilization substance protein B homolog Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UComplement component C8 gamma chain Not Available Humans URibonucleoside-diphosphate reductase subunit beta Not Available Mycobacterium leprae (strain TN) UGlutamine synthetase 1 Not Available Mycobacterium tuberculosis UCitrate synthase Not Available Antarctic bacterium DS2-3R UProstaglandin F synthase Not Available Trypanosoma brucei brucei UAdenine phosphoribosyltransferase Not Available Humans UGlucose-1-phosphate thymidylyltransferase Not Available Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) UBeta-lactamase 2 Not Available Bacillus cereus UGlyoxalase family protein Not Available Bacillus cereus (strain ATCC 14579 / DSM 31) ULaccase domain protein YfiH Not Available Escherichia coli (strain K12) URibose-5-phosphate isomerase A Not Available Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) UGMP synthase [glutamine-hydrolyzing] Not Available Escherichia coli (strain K12) AAldose reductase inhibitorHumans UInosine triphosphate pyrophosphatase Not Available Humans UCitrate synthase, mitochondrial Not Available Humans ULysozyme Not Available Enterobacteria phage P1 UGlycerol uptake operon antiterminator regulatory protein Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) U3-carboxy-cis,cis-muconate cycloisomerase Not Available Pseudomonas putida UProto-oncogene tyrosine-protein kinase Src Not Available Humans UPyruvate decarboxylase Not Available Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) URibonuclease pancreatic Not Available Humans AIsocitrate dehydrogenase [NADP] substrateinhibitorBacillus subtilis (strain 168) UEosinophil cationic protein Not Available Humans ABeta-lactamase weak inhibitorBacillus licheniformis AMetallo-beta-lactamase type 2 inhibitorKlebsiella pneumoniae - Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
ORAL (LD50): Acute: 5040 mg/kg [Mouse]. 3000 mg/kg [Rat].
- Affected organisms
- Humans and other mammals
- Pathways
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Unlock Additional DataAmphetamine The excretion of Amphetamine can be decreased when combined with Citric acid. Benzphetamine The excretion of Benzphetamine can be decreased when combined with Citric acid. Chlorpropamide Citric acid may decrease the excretion rate of Chlorpropamide which could result in a higher serum level. Demeclocycline The therapeutic efficacy of Demeclocycline can be decreased when used in combination with Citric acid. Dextroamphetamine The excretion of Dextroamphetamine can be decreased when combined with Citric acid. Diethylpropion The excretion of Diethylpropion can be decreased when combined with Citric acid. Doxycycline The therapeutic efficacy of Doxycycline can be decreased when used in combination with Citric acid. Eravacycline The therapeutic efficacy of Eravacycline can be decreased when used in combination with Citric acid. Iofetamine I-123 The excretion of Iofetamine I-123 can be decreased when combined with Citric acid. Lisdexamfetamine The excretion of Lisdexamfetamine can be decreased when combined with Citric acid. Additional Data Available- Extended DescriptionExtended Description
Extended description of the mechanism of action and particular properties of each drug interaction.
Learn more - Severity
- Evidence Level
- ActionAction
An effect category for each drug interaction. Know how this interaction affects the subject drug.
Learn more
- Food Interactions
- No interactions found.
Products
- Product Ingredients
Ingredient UNII CAS InChI Key Citric acid monohydrate 2968PHW8QP 5949-29-1 YASYEJJMZJALEJ-UHFFFAOYSA-N - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Unlock Additional DataACD Solution Modified Solution 8 mg/1mL Intravenous Anazao Health Corporation 2012-05-23 Not applicable US 
Citric Buffered Normal Saline Injection, solution 166 mg/270mL Intravenous Nabriva Therapeutics US, Inc. 2019-09-09 Not applicable US Additional Data Available- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Learn more
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Unlock Additional Databdr Re-action natural low base skin refiner exfoliation essence Liquid 1.5 g/30mL Topical Hanaim International Llc 2016-11-14 Not applicable US Citric Acid Liquid 5.6 g/100mL Topical Ashahi Chemicals USA LLC 2020-10-15 Not applicable US Citric Acid Wipes Liquid 0.88 g/100g Topical Ashahi Chemicals USA LLC 2020-03-30 Not applicable US Hand Washing Liquid 0.3 g/100g Topical NINGBO JIANGBEI OCEAN STAR TRADING CO.,LTD 2016-09-26 Not applicable US KID-CLEAN Epiguard (Herbage Basis germ Growth InhibitsSolution) Gel 104 g/100mL Topical KOREA JINTECH 2020-05-22 Not applicable US Lot Liquid 0.15 g/100g Topical Aurelio Muñoz Sagaón 2020-06-06 Not applicable US Stop Hair Spray 7 mg/1mL Topical Mila Beauty Pty Ltd 2012-07-01 Not applicable US Stop Hair Spray 0.7 mg/100mL Topical Stop Hair Pty Ltd 2012-09-01 Not applicable US Whitening Lemon Peel Liquid 0.007 g/1mL Topical Ami Cosmetic Co.,Ltd. 2013-08-31 2019-03-30 US Additional Data Available- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Learn more
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image A-C-D Solution Citric acid (80 mg) + Dextrose, unspecified form (132 mg) + Sodium citrate (250 mg) Liquid Intravenous Draximage A Division Of Draxis Specialty Pharmaceuticals Inc 1959-12-31 2003-07-08 Canada 
Acd A Citric acid monohydrate (0.8 g/100mL) + D-glucose monohydrate (2.45 g/100mL) + Sodium citrate dihydrate (2.2 g/100mL) Injection, solution Intravenous Terumo Bct, Ltd. 2002-02-25 Not applicable US Acd A Citric acid monohydrate (0.80 g/100mL) + D-glucose monohydrate (2.45 g/100mL) + Sodium citrate (2.2 g/100mL) Injection, solution Intravenous Terumo BCT Ltd 2002-02-25 Not applicable US Acd A Citric acid monohydrate (0.8 g/100mL) + D-glucose monohydrate (2.45 g/100mL) + Sodium citrate dihydrate (2.2 g/100mL) Injection, solution Intravenous Terumo Bct, Ltd. 2002-02-25 Not applicable US ACD Blood-Pack Units (PL 146 Plastic) Citric acid (493 mg/67.5mL) + D-glucose monohydrate (1.65 g/67.5mL) + Sodium citrate dihydrate (1.48 g/67.5mL) Solution Intravenous Fenwal, Inc. 2007-03-01 Not applicable US Acd-A Citric acid (730 mg/100mL) + D-glucose monohydrate (2.45 g/100mL) + Sodium citrate (2.2 g/100mL) Solution Intravenous Fenwal, Inc. 2012-10-24 Not applicable US Acd-A Citric acid monohydrate (0.73 g/100mL) + D-glucose monohydrate (2.45 g/100mL) + Sodium citrate (2.20 g/100mL) Solution Intravenous Haemonetics Corporation 1987-11-06 Not applicable US Acd-A Citric acid (3.65 g/500mL) + D-glucose monohydrate (12.25 g/500mL) + Sodium citrate (11 g/500mL) Solution Intravenous Fenwal, Inc. 2007-03-01 Not applicable US Additive Formula 3 Citric acid monohydrate (0.042 g/100mL) + Adenine (0.03 g/100mL) + D-glucose monohydrate (1.1 g/100mL) + Sodium chloride (0.41 g/100mL) + Sodium citrate dihydrate (0.59 g/100mL) + Sodium phosphate, monobasic, monohydrate (0.28 g/100mL) Solution Intravenous Terumo Bct, Ltd 2002-05-29 Not applicable US Additive Formula 3 Citric acid monohydrate (0.042 g/100mL) + Adenine (0.03 g/100mL) + D-glucose monohydrate (1.1 g/100mL) + Sodium chloride (0.41 g/100mL) + Sodium citrate dihydrate (0.59 g/100mL) + Sodium phosphate, monobasic, monohydrate (0.28 g/100mL) Solution Intravenous Terumo Bct, Ltd 2002-05-29 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image ACD Solution Modified Citric acid (8 mg/1mL) Solution Intravenous Anazao Health Corporation 2012-05-23 Not applicable US Anticoagulant Citrate Dextrose Solution-A Citric acid monohydrate (0.73 g/100mL) + Dextrose, unspecified form (2.45 g/100mL) + Sodium citrate (2.20 g/100mL) Solution Extracorporeal Biomet Biologics 2010-01-01 2010-09-06 US Av-1000 Citric acid monohydrate (0.06 g/100g) + Sodium chlorite (0.05 g/100g) Powder Topical Sejin E&P Co., Ltd. 2020-05-02 Not applicable US Av100 Citric acid monohydrate (0.06 g/100g) + Sodium chlorite (0.05 g/100g) Powder Topical Sejin E&P Co., Ltd. 2020-05-02 Not applicable US B100 Citric acid monohydrate (0.06 g/100g) + Sodium chlorite (0.05 g/100g) Powder Topical Sejin E&P Co., Ltd. 2020-05-02 Not applicable US bdr Re-action natural low base skin refiner exfoliation essence Citric acid monohydrate (1.5 g/30mL) Liquid Topical Hanaim International Llc 2016-11-14 Not applicable US Bt100s Citric acid monohydrate (0.06 g/100g) + Sodium chlorite (0.05 g/100g) Powder Topical Sejin E&P Co., Ltd. 2020-05-02 Not applicable US Cytra 3 Citric acid monohydrate (334 mg/5mL) + Potassium citrate (550 mg/5mL) + Sodium citrate (500 mg/5mL) Syrup Oral Pegasus Laboratories 2006-05-05 2009-10-17 US Cytra 3 Citric acid monohydrate (334 mg/5mL) + Potassium citrate (550 mg/5mL) + Sodium citrate (500 mg/5mL) Syrup Oral Cypress Pharmaceuticals, Inc 2008-07-29 2014-10-11 US Cytra-2 Citric acid monohydrate (334 mg/5mL) + Sodium citrate dihydrate (500 mg/5mL) Solution Oral Cypress Pharmaceuticals, Inc. 2008-10-01 2014-10-11 US
Categories
- ATC Codes
- A09AB04 — Citric acid
- Drug Categories
- Acid Preparations
- Acidifying Activity
- Acids, Acyclic
- Alimentary Tract and Metabolism
- Calcium Chelating Activity
- Calcium Chelating Agents
- Calculi Dissolution Agent
- Chelating Agents
- Citrates
- Compounds used in a research, industrial, or household setting
- Decreased Coagulation Factor Activity
- Digestives, Incl. Enzymes
- Hematologic Agents
- Sequestering Agents
- Tricarboxylic Acids
- Urinary Acidifying Agents
- Urinary Alkalinisers
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Tricarboxylic acids and derivatives
- Direct Parent
- Tricarboxylic acids and derivatives
- Alternative Parents
- Alpha hydroxy acids and derivatives / Tertiary alcohols / Carboxylic acids / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
- Substituents
- Alcohol / Aliphatic acyclic compound / Alpha-hydroxy acid / Carbonyl group / Carboxylic acid / Hydrocarbon derivative / Hydroxy acid / Organic oxide / Organic oxygen compound / Organooxygen compound
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- tricarboxylic acid (CHEBI:30769)
Chemical Identifiers
- UNII
- XF417D3PSL
- CAS number
- 77-92-9
- InChI Key
- KRKNYBCHXYNGOX-UHFFFAOYSA-N
- InChI
- InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
- IUPAC Name
- 2-hydroxypropane-1,2,3-tricarboxylic acid
- SMILES
- OC(=O)CC(O)(CC(O)=O)C(O)=O
References
- Synthesis Reference
Karl E. Wiegand, "Chemical process for producing citric acid." U.S. Patent US3962287, issued 0000.
US3962287- General References
- External Links
- Human Metabolome Database
- HMDB0000094
- KEGG Drug
- D00037
- KEGG Compound
- C00158
- PubChem Compound
- 311
- PubChem Substance
- 46508995
- ChemSpider
- 305
- BindingDB
- 14672
- 21183
- ChEBI
- 30769
- ChEMBL
- CHEMBL1261
- ZINC
- ZINC000000895081
- PharmGKB
- PA449021
- Guide to Pharmacology
- GtP Drug Page
- PDBe Ligand
- CIT
- Wikipedia
- Citric_acid
- PDB Entries
- 1a59 / 1afl / 1agr / 1aj8 / 1az2 / 1b1e / 1b1i / 1cts / 1cwv / 1cxu … show 1082 more
- MSDS
- Download (49.5 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Not Available Bowel preparation therapy 1 4 Completed Diagnostic Colonoscopy 1 4 Completed Diagnostic Hemodynamics / Hyponatremia 1 4 Completed Other End Stage Renal Disease (ESRD) 1 4 Completed Treatment Cathartic Colon 1 4 Completed Treatment Colonoscopy 1 4 Completed Treatment Dry Mouth / Hyposalivation / Quality of Life / Sjögren's Syndrome 1 4 Completed Treatment Intrabony Periodontal Defect 1 4 Completed Treatment Obstructive Sleep Apnea (OSA) / Psoriasis 1 4 Recruiting Diagnostic Bowel Preparation Solutions 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Liquid Intravenous Solution Intravenous 8 mg/1mL Solution Intravenous Suspension Topical 3 g/100mL Tablet, effervescent Oral Tablet Oral 324 mg Aerosol, spray Topical Injection, solution Extracorporeal Solution Unknown Solution Extracorporeal Solution Extracorporeal 0.8 g/100ml Powder Topical Liquid Topical 1.5 g/30mL Powder, for solution Oral Granule Oral Powder, for solution Oral 0.01 g Solution Hemodialysis Liquid Topical 5.6 g/100mL Solution Irrigation 20 g/100mL Liquid Topical 0.88 g/100g Injection, solution Intravenous 166 mg/270mL Kit Intravenous Syrup Oral Liquid Oral Solution Oral Granule, for solution Oral Powder 715.2 mg Capsule, delayed release pellets Oral Powder 1.85 g Powder 1.85 g/4.3g Powder 43.16 g/100g Powder 43.26 g/100g Powder 43.11 g/100g Solution Oral 500 mg/100mL Liquid Topical Liquid Topical 0.3 g/100g Solution Oral 369 mg Tablet, effervescent 1 g Tablet, effervescent Oral 2170 mg Gel Topical 104 g/100mL Liquid Topical 0.15 g/100g Solution Oral 6.67 g/100mL Gel Vaginal Powder, for solution Oral 10 mg Powder Oral Solution Oral 66.67 mg/1mL Solution Oral 1.25 g/100mL Kit Oral Powder, metered Oral Tablet, chewable Oral Powder, for solution Irrigation; Topical Solution Irrigation Granule, effervescent Oral Cloth Topical Powder; syrup Oral 6.39 g/100mL Solution Oral 70 mg/1mL Solution Oral 9.8 g/100mL Solution Oral 10 g/100mL Solution Oral 14 g/100mL Solution Oral 140 mg/1mL Solution Oral 6 g/100mL Solution Oral 6.9 g/100mL Solution Oral 7 g/100mL Injection, solution Intravenous Spray Topical 0.7 mg/100mL Spray Topical 7 mg/1mL Powder, for solution Oral 12 g Liquid Irrigation Syrup 0.1 g/100mL Liquid Topical 0.007 g/1mL - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region Unlock Additional DataUS8450338 No 2013-05-28 2028-10-10 US US8481083 No 2013-07-09 2028-10-10 US US9827231 No 2017-11-28 2034-06-23 US US10624879 No 2014-06-23 2034-06-23 US Additional Data Available- Filed On
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 153 °C PhysProp water solubility 5.92E+005 mg/L (at 20 °C) MERCK INDEX (1989) logP -1.64 AVDEEF,A (1997) logS 0.51 ADME Research, USCD pKa 2.79 SERJEANT,EP & DEMPSEY,B (1979) - Predicted Properties
Property Value Source Water Solubility 106.0 mg/mL ALOGPS logP -1.3 ALOGPS logP -1.3 ChemAxon logS -0.26 ALOGPS pKa (Strongest Acidic) 3.05 ChemAxon pKa (Strongest Basic) -4.2 ChemAxon Physiological Charge -3 ChemAxon Hydrogen Acceptor Count 7 ChemAxon Hydrogen Donor Count 4 ChemAxon Polar Surface Area 132.13 Å2 ChemAxon Rotatable Bond Count 5 ChemAxon Refractivity 35.62 m3·mol-1 ChemAxon Polarizability 15.54 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption - 0.7518 Blood Brain Barrier + 0.855 Caco-2 permeable - 0.8634 P-glycoprotein substrate Non-substrate 0.6125 P-glycoprotein inhibitor I Non-inhibitor 0.9694 P-glycoprotein inhibitor II Non-inhibitor 0.9658 Renal organic cation transporter Non-inhibitor 0.9624 CYP450 2C9 substrate Non-substrate 0.8641 CYP450 2D6 substrate Non-substrate 0.8932 CYP450 3A4 substrate Non-substrate 0.6809 CYP450 1A2 substrate Non-inhibitor 0.9336 CYP450 2C9 inhibitor Non-inhibitor 0.9399 CYP450 2D6 inhibitor Non-inhibitor 0.9476 CYP450 2C19 inhibitor Non-inhibitor 0.9396 CYP450 3A4 inhibitor Non-inhibitor 0.8735 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9904 Ames test Non AMES toxic 0.9132 Carcinogenicity Non-carcinogens 0.8206 Biodegradation Ready biodegradable 0.6288 Rat acute toxicity 1.7748 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9948 hERG inhibition (predictor II) Non-inhibitor 0.9577
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Targets
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Fumarate hydratase activity
- Specific Function
- Catalyzes the reversible addition of water to fumarate to give L-malate.
- Gene Name
- fumC
- Uniprot ID
- P05042
- Uniprot Name
- Fumarate hydratase class II
- Molecular Weight
- 50488.44 Da
References
- Weaver T, Banaszak L: Crystallographic studies of the catalytic and a second site in fumarase C from Escherichia coli. Biochemistry. 1996 Nov 5;35(44):13955-65. [PubMed:8909293]
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- Curator comments
- Literature referenced did research on target in T. brucei.
- General Function
- 6-phosphogluconolactonase activity
- Specific Function
- Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
- Gene Name
- pgl
- Uniprot ID
- Q9X0N8
- Uniprot Name
- 6-phosphogluconolactonase
- Molecular Weight
- 25324.955 Da
References
- Duclert-Savatier N, Poggi L, Miclet E, Lopes P, Ouazzani J, Chevalier N, Nilges M, Delarue M, Stoven V: Insights into the enzymatic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei using structural data and molecular dynamics simulation. J Mol Biol. 2009 May 22;388(5):1009-21. doi: 10.1016/j.jmb.2009.03.063. Epub 2009 Apr 1. [PubMed:19345229]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- L-amino-acid oxidase activity
- Specific Function
- Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity).
- Gene Name
- IL4I1
- Uniprot ID
- Q96RQ9
- Uniprot Name
- L-amino-acid oxidase
- Molecular Weight
- 62880.52 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RN...
- Gene Name
- CTDSP1
- Uniprot ID
- Q9GZU7
- Uniprot Name
- Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
- Molecular Weight
- 29202.94 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Marinobacter hydrocarbonoclasticus
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- P83787
- Uniprot Name
- Cytochrome c peroxidase
- Molecular Weight
- 35354.415 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Protein domain specific binding
- Specific Function
- Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct...
- Gene Name
- HGS
- Uniprot ID
- O14964
- Uniprot Name
- Hepatocyte growth factor-regulated tyrosine kinase substrate
- Molecular Weight
- 86191.46 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Yersinia pseudotuberculosis serotype I (strain IP32953)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Invasin is a protein that allows enteric bacteria to penetrate cultured mammalian cells. The entry of invasin in the cell is mediated by binding several beta-1 chain integrins.
- Gene Name
- Not Available
- Uniprot ID
- P11922
- Uniprot Name
- Invasin
- Molecular Weight
- 106543.46 Da
- Kind
- Protein
- Organism
- Enterobacteria phage T4
- Pharmacological action
- Unknown
- General Function
- Endonuclease activity
- Specific Function
- This endonuclease is specific to the thymidylate synthase (td) gene splice junction and is involved in intron homing.
- Gene Name
- ITEVIR
- Uniprot ID
- P13299
- Uniprot Name
- Intron-associated endonuclease 1
- Molecular Weight
- 28232.2 Da
- Kind
- Protein
- Organism
- Enterobacteria phage T4
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Structural component of the short tail fiber. Adhesion protein that binds irreversibly to the lipopolysaccharides component (LPS) on the cell surface of Escherichia coli B strains during virus atta...
- Gene Name
- 12
- Uniprot ID
- P10930
- Uniprot Name
- Short tail fiber protein gp12
- Molecular Weight
- 56204.88 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Poly(a) rna binding
- Specific Function
- Not Available
- Gene Name
- MDH2
- Uniprot ID
- P40926
- Uniprot Name
- Malate dehydrogenase, mitochondrial
- Molecular Weight
- 35502.935 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Acetobacter aceti
- Pharmacological action
- Unknown
- General Function
- 5-(carboxyamino)imidazole ribonucleotide mutase activity
- Specific Function
- Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
- Gene Name
- purE
- Uniprot ID
- Q2QJL3
- Uniprot Name
- N5-carboxyaminoimidazole ribonucleotide mutase
- Molecular Weight
- 18734.295 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Structural constituent of ribosome
- Specific Function
- One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with diff...
- Gene Name
- rplD
- Uniprot ID
- P38516
- Uniprot Name
- 50S ribosomal protein L4
- Molecular Weight
- 26630.77 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Not Available
- Gene Name
- CPB1
- Uniprot ID
- P15086
- Uniprot Name
- Carboxypeptidase B
- Molecular Weight
- 47367.11 Da
- Kind
- Protein
- Organism
- HAdV-2
- Pharmacological action
- Unknown
- General Function
- Structural molecule activity
- Specific Function
- Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chap...
- Gene Name
- Not Available
- Uniprot ID
- P03277
- Uniprot Name
- Hexon protein
- Molecular Weight
- 109151.995 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Riboflavin kinase activity
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9WZW1
- Uniprot Name
- Riboflavin biosynthesis protein
- Molecular Weight
- 33613.56 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Sucrose alpha-glucosidase activity
- Specific Function
- Hydrolysis of sucrose, raffinose, inulin and levan. Specific for the fructose moiety and the beta-anomeric configuration of the glycosidic linkages of its substrates. The enzyme released fructose f...
- Gene Name
- bfrA
- Uniprot ID
- O33833
- Uniprot Name
- Beta-fructosidase
- Molecular Weight
- 49841.065 Da
- Kind
- Protein
- Organism
- Yersinia pestis
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- sspA
- Uniprot ID
- A0A384KMD8
- Uniprot Name
- Putative stringent starvation protein A
- Molecular Weight
- 24524.98 Da
- Kind
- Protein
- Organism
- Thermus thermophilus
- Pharmacological action
- Unknown
- General Function
- Transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
- Specific Function
- Not Available
- Gene Name
- cit
- Uniprot ID
- Q9LCX9
- Uniprot Name
- Citrate synthase
- Molecular Weight
- 42322.13 Da
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Rna-3'-phosphate cyclase activity
- Specific Function
- Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) trans...
- Gene Name
- rtcA
- Uniprot ID
- P46849
- Uniprot Name
- RNA 3'-terminal phosphate cyclase
- Molecular Weight
- 35902.925 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Poly(a) rna binding
- Specific Function
- Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their sub...
- Gene Name
- LSM6
- Uniprot ID
- P62312
- Uniprot Name
- U6 snRNA-associated Sm-like protein LSm6
- Molecular Weight
- 9127.525 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Phosphatidylinositol-3,4-bisphosphate binding
- Specific Function
- Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.
- Gene Name
- PLEKHA1
- Uniprot ID
- Q9HB21
- Uniprot Name
- Pleckstrin homology domain-containing family A member 1
- Molecular Weight
- 45553.165 Da
- Kind
- Protein
- Organism
- Serratia marcescens
- Pharmacological action
- Unknown
- General Function
- Transporter activity
- Specific Function
- Part of the ABC transporter complex FbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. This protein specifically binds Fe(3+) and is involved in its transmembrane transport (By similarity).
- Gene Name
- fbpA
- Uniprot ID
- P21408
- Uniprot Name
- Fe(3+)-binding periplasmic protein
- Molecular Weight
- 36157.015 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Gtpase activity
- Specific Function
- Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-n...
- Gene Name
- ftsY
- Uniprot ID
- Q9WZ40
- Uniprot Name
- Signal recognition particle receptor FtsY
- Molecular Weight
- 32045.975 Da
- Kind
- Protein
- Organism
- Shigella flexneri
- Pharmacological action
- Unknown
- General Function
- Nicotinate-nucleotide adenylyltransferase activity
- Specific Function
- Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
- Gene Name
- nadD
- Uniprot ID
- P0A753
- Uniprot Name
- Nicotinate-nucleotide adenylyltransferase
- Molecular Weight
- 24527.75 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Rna binding
- Specific Function
- Involved in the transcription termination process.
- Gene Name
- nusB
- Uniprot ID
- Q9X286
- Uniprot Name
- N utilization substance protein B homolog
- Molecular Weight
- 16973.325 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Retinol binding
- Specific Function
- C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit se...
- Gene Name
- C8G
- Uniprot ID
- P07360
- Uniprot Name
- Complement component C8 gamma chain
- Molecular Weight
- 22277.285 Da
- Kind
- Protein
- Organism
- Mycobacterium leprae (strain TN)
- Pharmacological action
- Unknown
- General Function
- Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
- Specific Function
- Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
- Gene Name
- nrdF
- Uniprot ID
- Q9CBQ2
- Uniprot Name
- Ribonucleoside-diphosphate reductase subunit beta
- Molecular Weight
- 37315.67 Da
- Kind
- Protein group
- Organism
- Mycobacterium tuberculosis
- Pharmacological action
- Unknown
- General Function
- Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia (PubMed:7937767, PubMed:12819079). Also able to use GTP (PubMed:7937767). D-glutamate is a poor substrate, and DL-glutamate shows about 50% of the standard specific activity (PubMed:7937767). Also plays a key role in controlling the ammonia levels within infected host cells and so contributes to the pathogens capacity to inhibit phagosome acidification and phagosome-lysosome fusion (PubMed:7937767, PubMed:12819079). Involved in cell wall biosynthesis via the production of the major component poly-L-glutamine (PLG) (PubMed:7937767, PubMed:10618433). PLG synthesis in the cell wall occurs only in nitrogen limiting conditions and on the contrary high nitrogen conditions inhibit PLG synthesis (Probable).
- Specific Function
- Atp binding
Components:
| Name | UniProt ID |
|---|---|
| Glutamine synthetase | P9WN39 |
| Glutamine synthetase | P9WN38 |
- Kind
- Protein
- Organism
- Antarctic bacterium DS2-3R
- Pharmacological action
- Unknown
- General Function
- Citrate synthase activity
- Specific Function
- Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes...
- Gene Name
- gltA
- Uniprot ID
- O34002
- Uniprot Name
- 2-methylcitrate synthase
- Molecular Weight
- 41832.0 Da
- Kind
- Protein
- Organism
- Trypanosoma brucei brucei
- Pharmacological action
- Unknown
- General Function
- Prostaglandin-f synthase activity
- Specific Function
- Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity towards the synthetic substrates 9,10-phenanthrenequinone and p-nitroben...
- Gene Name
- Not Available
- Uniprot ID
- Q9GV41
- Uniprot Name
- Prostaglandin F synthase
- Molecular Weight
- 30992.385 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Amp binding
- Specific Function
- Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
- Gene Name
- APRT
- Uniprot ID
- P07741
- Uniprot Name
- Adenine phosphoribosyltransferase
- Molecular Weight
- 19607.535 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Pharmacological action
- Unknown
- General Function
- Nucleotide binding
- Specific Function
- Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.
- Gene Name
- rmlA
- Uniprot ID
- Q9HU22
- Uniprot Name
- Glucose-1-phosphate thymidylyltransferase
- Molecular Weight
- 32456.65 Da
- Kind
- Protein
- Organism
- Bacillus cereus
- Pharmacological action
- Unknown
- Curator comments
- There exists a vague and elusive relationship between drug and target, more research is warranted.
- General Function
- Zinc ion binding
- Specific Function
- Can hydrolyze carbapenem compounds.
- Gene Name
- blm
- Uniprot ID
- P04190
- Uniprot Name
- Beta-lactamase 2
- Molecular Weight
- 28092.24 Da
References
- Coles NW, Gross R: Exopenicillinase synthesis in Staphylococcus aureus. J Bacteriol. 1969 May;98(2):659-61. [PubMed:5784217]
- Kind
- Protein
- Organism
- Bacillus cereus (strain ATCC 14579 / DSM 31)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q81F54
- Uniprot Name
- Glyoxalase family protein
- Molecular Weight
- 16581.885 Da
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Copper ion binding
- Specific Function
- Not Available
- Gene Name
- yfiH
- Uniprot ID
- P33644
- Uniprot Name
- Laccase domain protein YfiH
- Molecular Weight
- 26338.69 Da
- Kind
- Protein
- Organism
- Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
- Pharmacological action
- Unknown
- General Function
- Ribose-5-phosphate isomerase activity
- Specific Function
- Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
- Gene Name
- rpiA
- Uniprot ID
- P44725
- Uniprot Name
- Ribose-5-phosphate isomerase A
- Molecular Weight
- 23093.47 Da
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Pyrophosphatase activity
- Specific Function
- Catalyzes the synthesis of GMP from XMP.
- Gene Name
- guaA
- Uniprot ID
- P04079
- Uniprot Name
- GMP synthase [glutamine-hydrolyzing]
- Molecular Weight
- 58678.78 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Glyceraldehyde oxidoreductase activity
- Specific Function
- Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
- Gene Name
- AKR1B1
- Uniprot ID
- P15121
- Uniprot Name
- Aldose reductase
- Molecular Weight
- 35853.125 Da
References
- Harrison DH, Bohren KM, Ringe D, Petsko GA, Gabbay KH: An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate. Biochemistry. 1994 Mar 1;33(8):2011-20. doi: 10.1021/bi00174a006. [PubMed:8117658]
- Biadene M, Hazemann I, Cousido A, Ginell S, Joachimiak A, Sheldrick GM, Podjarny A, Schneider TR: The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop. Acta Crystallogr D Biol Crystallogr. 2007 Jun;63(Pt 6):665-72. Epub 2007 May 15. [PubMed:17505104]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Xtp diphosphatase activity
- Specific Function
- Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) an...
- Gene Name
- ITPA
- Uniprot ID
- Q9BY32
- Uniprot Name
- Inosine triphosphate pyrophosphatase
- Molecular Weight
- 21445.495 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Poly(a) rna binding
- Specific Function
- Not Available
- Gene Name
- CS
- Uniprot ID
- O75390
- Uniprot Name
- Citrate synthase, mitochondrial
- Molecular Weight
- 51712.025 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Enterobacteria phage P1
- Pharmacological action
- Unknown
- General Function
- Lysozyme activity
- Specific Function
- Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.
- Gene Name
- 17
- Uniprot ID
- Q37875
- Uniprot Name
- Lysozyme
- Molecular Weight
- 20256.17 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9X1F0
- Uniprot Name
- Glycerol uptake operon antiterminator regulatory protein
- Molecular Weight
- 19296.645 Da
- Kind
- Protein
- Organism
- Pseudomonas putida
- Pharmacological action
- Unknown
- General Function
- 3-carboxy-cis,cis-muconate cycloisomerase activity
- Specific Function
- Catalyzes an anti cycloisomerization.
- Gene Name
- pcaB
- Uniprot ID
- P32427
- Uniprot Name
- 3-carboxy-cis,cis-muconate cycloisomerase
- Molecular Weight
- 44675.755 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Sh3/sh2 adaptor activity
- Specific Function
- Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion recept...
- Gene Name
- SRC
- Uniprot ID
- P12931
- Uniprot Name
- Proto-oncogene tyrosine-protein kinase Src
- Molecular Weight
- 59834.295 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
- Pharmacological action
- Unknown
- General Function
- Thiamine pyrophosphate binding
- Specific Function
- Not Available
- Gene Name
- pdc
- Uniprot ID
- P06672
- Uniprot Name
- Pyruvate decarboxylase
- Molecular Weight
- 60925.005 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Ribonuclease a activity
- Specific Function
- Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.
- Gene Name
- RNASE1
- Uniprot ID
- P07998
- Uniprot Name
- Ribonuclease pancreatic
- Molecular Weight
- 17644.125 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Yes
- Actions
- SubstrateInhibitor
- Curator comments
- Drug is inhibitor for fungal version of target.
- General Function
- Nad binding
- Specific Function
- Not Available
- Gene Name
- icd
- Uniprot ID
- P39126
- Uniprot Name
- Isocitrate dehydrogenase [NADP]
- Molecular Weight
- 46417.39 Da
References
- Sadka A, Dahan E, Or E, Cohen L: NADP(+)-isocitrate dehydrogenase gene expression and isozyme activity during citrus fruit development. Plant Sci. 2000 Sep 8;158(1-2):173-181. doi: 10.1016/s0168-9452(00)00328-9. [PubMed:10996257]
- Agrawal PK, Bhatt CS, Viswanathan L: Inhibition of fungal NADP+-isocitrate dehydrogenase by citric acid. Z Allg Mikrobiol. 1983;23(6):403-6. doi: 10.1002/jobm.3630230613. [PubMed:6636842]
- Kobayashi K, Hattori T, Hayashi R, Kirimura K: Overexpression of the NADP+-specific isocitrate dehydrogenase gene (icdA) in citric acid-producing Aspergillus niger WU-2223L. Biosci Biotechnol Biochem. 2014;78(7):1246-53. doi: 10.1080/09168451.2014.918483. Epub 2014 Jun 17. [PubMed:25229866]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Ribonuclease activity
- Specific Function
- Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolariza...
- Gene Name
- RNASE3
- Uniprot ID
- P12724
- Uniprot Name
- Eosinophil cationic protein
- Molecular Weight
- 18385.145 Da
References
- Structure Of Ecp In Complex With Citrate Ions [Link]
- Kind
- Protein
- Organism
- Bacillus licheniformis
- Pharmacological action
- Yes
- Actions
- Weak inhibitor
- General Function
- Beta-lactamase activity
- Specific Function
- Not Available
- Gene Name
- penP
- Uniprot ID
- P00808
- Uniprot Name
- Beta-lactamase
- Molecular Weight
- 33995.36 Da
References
- Beck J, Sauvage E, Charlier P, Marchand-Brynaert J: 2-Aminopropane-1,2,3-tricarboxylic acid: Synthesis and co-crystallization with the class A beta-lactamase BS3 of Bacillus licheniformis. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3764-8. doi: 10.1016/j.bmcl.2008.05.045. Epub 2008 May 16. [PubMed:18515103]
- Kind
- Protein
- Organism
- Klebsiella pneumoniae
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
- Specific Function
- Beta-lactamase activity
- Gene Name
- blaNDM-1
- Uniprot ID
- C7C422
- Uniprot Name
- Metallo-beta-lactamase type 2
- Molecular Weight
- 28499.225 Da
References
- Kumar R, Chandar B, Parani M: Use of succinic & oxalic acid in reducing the dosage of colistin against New Delhi metallo-beta-lactamase-1 bacteria. Indian J Med Res. 2018 Jan;147(1):97-101. doi: 10.4103/ijmr.IJMR_1407_16. [PubMed:29749367]
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
- Gene Name
- SLCO2B1
- Uniprot ID
- O94956
- Uniprot Name
- Solute carrier organic anion transporter family member 2B1
- Molecular Weight
- 76709.98 Da
References
- Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther. 2003 Aug;306(2):703-8. Epub 2003 Apr 30. [PubMed:12724351]
Drug created on June 13, 2005 07:24 / Updated on June 12, 2020 11:41
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