Glutathione peroxidase 3

BE0000821ProteinHumansGPX3

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. It is acted on by 2 drugs in DrugBank.

Gene name
GPX3
UniProtKB entry
P22352Swiss-Prot
Cellular location
Secreted
Residues / weight
226 residues · 25,552 Da
Also known as
1.11.1.9 · Extracellular glutathione peroxidase · GPx-3 · GPx-P · GPXP

Resolves to

Protein
UniProtP22352UniProt nameGPX3_HUMAN
Gene
HGNCHGNC:4555NCBI Gene2878GenBank2160390GeneCardsGPX3
Pharmacology
KEGGhsa:2878
Structure
PDB2R37
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutathione peroxidase 3, how selective are they, and which programs against it are still in active trials?

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