Metabotropic glutamate receptor 7

BE0000834ProteinHumansGRM7

G protein-coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed:33500274). It is acted on by 1 drug in DrugBank.

Gene name
GRM7
UniProtKB entry
Q14831Swiss-Prot
Cellular location
Cell membrane
Residues / weight
915 residues · 102,250 Da
Also known as
GPRC1G · MGLUR7

Resolves to

Protein
UniProtQ14831UniProt nameGRM7_HUMAN
Gene
HGNCHGNC:4599NCBI Gene2917GenBank1370111GeneCardsGRM7
Pharmacology
IUPHAR/GtoPdb295KEGGhsa:2917
Structure
PDB3MQ4PDB5C5CPDB7EPC
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Metabotropic glutamate receptor 7, how selective are they, and which programs against it are still in active trials?

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