Hydroxycarboxylic acid receptor 3

BE0000836ProteinHumansHCAR3

G protein-coupled receptor for 3-hydroxyoctanoate, a fatty acid beta-oxidation intermediate. It is acted on by 3 drugs in DrugBank.

Gene name
HCAR3
UniProtKB entry
P49019Swiss-Prot
Cellular location
Cell membrane
Residues / weight
387 residues · 44,478 Da
Also known as
G protein-coupled receptor 109B · G protein-coupled receptor HM74 · G protein-coupled receptor HM74B · GPR109B · HCA3

Resolves to

Protein
UniProtP49019UniProt nameHCAR3_HUMAN
Gene
HGNCHGNC:16824NCBI Gene8843GenBank219867GeneCardsHCAR3
Pharmacology
IUPHAR/GtoPdb313KEGGhsa:8843
Structure
PDB8IHJPDB8IHKPDB8JEF
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hydroxycarboxylic acid receptor 3, how selective are they, and which programs against it are still in active trials?

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