Tyrosine-protein kinase Fyn

BE0000839ProteinHumansFYN

Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660,... It is acted on by 4 drugs in DrugBank.

Gene name
FYN
UniProtKB entry
P06241Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
537 residues · 60,761 Da
Also known as
2.7.10.2 · p59-Fyn · Proto-oncogene c-Fyn · Proto-oncogene Syn · SLK

Resolves to

Protein
UniProtP06241UniProt nameFYN_HUMAN
Gene
HGNCHGNC:4037NCBI Gene2534GenBank338228GeneCardsFYN
Pharmacology
IUPHAR/GtoPdb2026KEGGhsa:2534
Structure
PDB10DJPDB1A0NPDB1AOT
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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40GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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66+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase Fyn, how selective are they, and which programs against it are still in active trials?

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