Tyrosine-protein kinase Yes

BE0000840ProteinHumansYES1

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. It is acted on by 2 drugs in DrugBank.

Gene name
YES1
UniProtKB entry
P07947Swiss-Prot
Cellular location
Cell membrane
Residues / weight
543 residues · 60,801 Da
Also known as
2.7.10.2 · p61-Yes · Proto-oncogene c-Yes · YES

Resolves to

Protein
UniProtP07947UniProt nameYES_HUMAN
Gene
HGNCHGNC:12841NCBI Gene7525GenBank181268GeneCardsYES1
Pharmacology
IUPHAR/GtoPdb2284KEGGhsa:7525
Structure
PDB2HDA
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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16GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase Yes, how selective are they, and which programs against it are still in active trials?

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