Ephrin type-A receptor 2

BE0000841ProteinHumansEPHA2

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. It is acted on by 7 drugs in DrugBank.

Gene name
EPHA2
UniProtKB entry
P29317Swiss-Prot
Cellular location
Cell membrane
Residues / weight
976 residues · 108,266 Da
Also known as
2.7.10.1 · ECK · Epithelial cell kinase · Tyrosine-protein kinase receptor ECK

Resolves to

Protein
UniProtP29317UniProt nameEPHA2_HUMAN
Gene
HGNCHGNC:3386NCBI Gene1969GenBank181944GeneCardsEPHA2
Pharmacology
IUPHAR/GtoPdb1822KEGGhsa:1969
Structure
PDB1MQBPDB2E8NPDB2K9Y
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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10Clinical trialsTrials of drugs acting on it, by phase and status
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15GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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52+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ephrin type-A receptor 2, how selective are they, and which programs against it are still in active trials?

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