T-lymphocyte activation antigen CD80

BE0000847ProteinHumansCD80

Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:38467718). It is acted on by 3 drugs in DrugBank.

Gene name
CD80
UniProtKB entry
P33681Swiss-Prot
Cellular location
Cell membrane
Residues / weight
288 residues · 33,048 Da
Also known as
Activation B7-1 antigen · B7 · BB1 · CD28LG · CD28LG1

Resolves to

Protein
UniProtP33681UniProt nameCD80_HUMAN
Gene
HGNCHGNC:1700NCBI Gene941GenBank306916GeneCardsCD80
Pharmacology
IUPHAR/GtoPdb2744KEGGhsa:941
Structure
PDB1DR9PDB1I8LPDB7TPS
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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21Clinical trialsTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on T-lymphocyte activation antigen CD80, how selective are they, and which programs against it are still in active trials?

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