Complement C5

BE0000855ProteinHumansC5

Precursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune... It is acted on by 22 drugs in DrugBank.

Gene name
C5
UniProtKB entry
P01031Swiss-Prot
Cellular location
Secreted
Residues / weight
1,676 residues · 188,304 Da
Also known as
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 · CPAMD4

Resolves to

Protein
UniProtP01031UniProt nameCO5_HUMAN
Gene
HGNCHGNC:1331NCBI Gene727GenBank179983GeneCardsC5
Pharmacology
KEGGhsa:727
Structure
PDB1CFAPDB1KJSPDB1XWE
Drugs

What you can answer from here — as of September 07, 2019

22DrugsApproved to experimental, with action, bond type and pharmacological action
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18Clinical trialsTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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11Pfam domainsDomain architecture mapped to Pfam families and clans
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83+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Complement C5, how selective are they, and which programs against it are still in active trials?

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