Receptor activity-modifying protein 2

BE0000860ProteinHumansRAMP2

Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:9620797). It is acted on by 1 drug in DrugBank.

Gene name
RAMP2
UniProtKB entry
O60895Swiss-Prot
Cellular location
Cell membrane
Residues / weight
175 residues · 19,607 Da
Also known as
Calcitonin-receptor-like receptor activity-modifying protein 2 · CRLR activity-modifying protein 2

Resolves to

Protein
UniProtO60895UniProt nameRAMP2_HUMAN
Gene
HGNCHGNC:9844NCBI Gene10266GenBank3171912GeneCardsRAMP2
Pharmacology
IUPHAR/GtoPdb52KEGGhsa:10266
Structure
PDB2XVTPDB3AQEPDB3AQF
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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24GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Receptor activity-modifying protein 2, how selective are they, and which programs against it are still in active trials?

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