L-xylulose reductase

BE0000869ProteinHumansDCXR

Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose (PubMed:11882650, PubMed:19337691, PubMed:40737316). It is acted on by 2 drugs in DrugBank.

Gene name
DCXR
UniProtKB entry
Q7Z4W1Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
244 residues · 25,913 Da
Also known as
1.1.1.10 · DCXR · Dicarbonyl/L-xylulose reductase · kiDCR · Kidney dicarbonyl reductase

Resolves to

Protein
UniProtQ7Z4W1UniProt nameDCXR_HUMAN
Gene
HGNCHGNC:18985NCBI Gene51181GenBank15425623GeneCardsDCXR
Pharmacology
KEGGhsa:51181
Structure
PDB1PR9PDB1WNTPDB3D3W
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on L-xylulose reductase, and which indications are they being tested in?

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