Protein-tyrosine kinase 2-beta

BE0000871ProteinHumansPTK2B

Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. It is acted on by 7 drugs in DrugBank.

Gene name
PTK2B
UniProtKB entry
Q14289Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,009 residues · 115,874 Da
Also known as
2.7.10.2 · CADTK · CAK-beta · CAKB · Calcium-dependent tyrosine kinase

Resolves to

Protein
UniProtQ14289UniProt nameFAK2_HUMAN
Gene
HGNCHGNC:9612NCBI Gene2185GenBank988305GeneCardsPTK2B
Pharmacology
IUPHAR/GtoPdb2181KEGGhsa:2185
Structure
PDB2LK4PDB3CC6PDB3ET7
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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60GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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64+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein-tyrosine kinase 2-beta, how selective are they, and which programs against it are still in active trials?

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