Protein kinase C beta type

BE0000872ProteinHumansPRKCB

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. It is acted on by 12 drugs in DrugBank.

Gene name
PRKCB
UniProtKB entry
P05771Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
671 residues · 76,868 Da
Also known as
2.7.11.13 · PKC-B · PKC-beta · PKCB · PRKCB1

Resolves to

Protein
UniProtP05771UniProt nameKPCB_HUMAN
Gene
HGNCHGNC:9395NCBI Gene5579GenBank189969GeneCardsPRKCB
Pharmacology
IUPHAR/GtoPdb1483KEGGhsa:5579
Structure
PDB2I0EPDB8SE1PDB8SE2
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
3Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
24GO termsFunction, process and component, as structured annotations
Sign in
4Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
56+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Protein kinase C beta type, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In