CTP synthase 1

BE0000874ProteinHumansCTPS1

CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids (PubMed:16179339, PubMed:17189248, PubMed:17463002, PubMed:24870241, PubMed:28459447, PubMed:34583994). It is acted on by 3 drugs in DrugBank.

Gene name
CTPS1
UniProtKB entry
P17812Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
591 residues · 66,690 Da
Also known as
6.3.4.2 · CTP synthetase 1 · CTPS · Protein-asparagine deamidase CTPS1 · UTP--ammonia ligase 1

Resolves to

Protein
UniProtP17812UniProt namePYRG1_HUMAN
Gene
HGNCHGNC:2519NCBI Gene1503GenBank30293GeneCardsCTPS1
Pharmacology
IUPHAR/GtoPdb3215KEGGhsa:1503
Structure
PDB2VO1PDB5U03PDB7MGZ
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on CTP synthase 1, how selective are they, and which programs against it are still in active trials?

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