Lanosterol 14-alpha demethylase

BE0000875ProteinHumansCYP51A1

Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis (PubMed:20149798, PubMed:8619637,... It is acted on by 6 drugs in DrugBank.

Gene name
CYP51A1
UniProtKB entry
Q16850Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
509 residues · 57,278 Da
Also known as
1.14.14.154 · CYP51 · CYP51A1 · CYPLI · Cytochrome P450 51A1

Resolves to

Protein
UniProtQ16850UniProt nameCP51A_HUMAN
Gene
HGNCHGNC:2649NCBI Gene1595GenBank1698396GeneCardsCYP51A1
Pharmacology
IUPHAR/GtoPdb1374KEGGhsa:1595
Structure
PDB3JUSPDB3JUVPDB3LD6
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lanosterol 14-alpha demethylase, how selective are they, and which programs against it are still in active trials?

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