Tioconazole is an imidazole antifungal used to treat vulvovaginal candidiasis. Topical formulations are used for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus".
- Mechanism
- Curator reviewed
Tioconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Tioconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.
- Primary indication
- For the local treatment of vulvovaginal candidiasis (moniliasis).Curator reviewed · 8 structured indications
- Formula / weight
- C16H13Cl3N2OS · 387.711 g/mol (avg)
- First approval
- Canada, 2000 · United States, 1997
- Brand names
Resolves to
QXHHHPZILQDDPS-UHFFFAOYSA-NSMILESClC1=C(COC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=CS1What you can answer from here — as of October 01, 2026
Which drugs share a target with Tioconazole, and which of those have an active Phase 3 trial?
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