N-acetylgalactosamine-6-sulfatase

BE0000883ProteinHumansGALNS

Lysosomal enzyme that hydrolyzes sulfate groups from glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S). It is acted on by 2 drugs in DrugBank.

Gene name
GALNS
UniProtKB entry
P34059Swiss-Prot
Cellular location
Lysosome
Residues / weight
522 residues · 58,026 Da
Also known as
3.1.6.4 · Chondroitinase · Chondroitinsulfatase · Galactose-6-sulfate sulfatase · GalN6S

Resolves to

Protein
UniProtP34059UniProt nameGALNS_HUMAN
Gene
HGNCHGNC:4122NCBI Gene2588GenBank870751GeneCardsGALNS
Pharmacology
KEGGhsa:2588
Structure
PDB4FDIPDB4FDJ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on N-acetylgalactosamine-6-sulfatase, how selective are they, and which programs against it are still in active trials?

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