Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Chondroitin sulfate
- DrugBank Accession Number
- DB09301
- Background
Chondroitin sulfate is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA).1 The SYSADOA status suggested a pain relief and increased joint mobility after a relative long regular administration, as well as a long-lasting effect after the end of the treatment. Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine and 1,4-β-d-glucuronic acid units which bear 4-O- and/or 6-O-sulfations at the N-acetylgalactosamine units disposed of in specific patterns. Depending on the predominating disaccharide unit, it will present different biological activities.2 Chondroitin sulfate is sold as an OTC dietary supplement in North America and it is a prescription drug under the EMA in Europe.4
- Type
- Small Molecule
- Groups
- Approved, Investigational, Nutraceutical
- Synonyms
- Chondroitin sulfates
- Condroitín sulfato
Pharmacology
- Indication
Chondroitin sulfate, used with glucosamine, is indicated to alleviate pain and inflammation from primary osteoarthritis.7 This supplement is reported to improve joint function and slow disease progression.8 Osteoarthritis is characterized by progressive structural and metabolic changes in joint tissues, mainly cartilage degradation, subchondral bone sclerosis and inflammation of synovial membrane.4
Studies have proposed the potential use of chondroitin sulfate as a nutraceutical in dietary supplements.3
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Symptomatic treatment of Arthritis ••• ••••• Symptomatic treatment of Backache ••• ••••• Symptomatic treatment of Muscle pain ••• ••••• Symptomatic treatment of Muscle strain ••• ••••• Symptomatic treatment of Muscle ache ••• ••••• - Associated Therapies
- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
In clinical trials, chondroitin sulfate has been reported a significant pain relief. Some reports have shown no slow in joint damage. The effects of chondroitin sulfate have been very controversial.8 One of the characteristics of chondroitin is a slow onset of action with a maximal effect attained after several months.4 Chondroitin sulfate has been reported to have anti-inflammatory properties by reducing the synovitis and prevent proinflammatory cytokine up-regulation in arthritis models.4
It is also registered an anabolic effect of chondroitin sulfate in which it induces the synthesis of hyaluronate in synovial cells, it increases type II collagen and proteoglycan synthesis.4
- Mechanism of action
Chondroitin sulfate functions as a major component of the intricate extracellular matrix. It is proposed that chondroitin sulfate supply can provide new building blocks for the synthesis of new matrix components.4
The anti-inflammatory effect of chondroitin sulfate is thought to be caused by the inhibition of the synthesis of inflammatory intermediates such as the inhibition of nitric oxide synthase, COX-2, microsomal prostaglandin synthase 1 and prostaglandin E2. It is reported also an inhibitory activity in the toll-like receptor 4 which will later inhibit inflammatory cytokines, NFkB and MyD88. This activity suggests a modulation of the MAP kinase pathway. On the other hand, some reports have pointed out an induction on the PKC/PI3K/Akt pathway in neuroblastoma.4
The anabolic effect of chondroitin sulfate is suggested to be caused by the inhibition of metalloproteinases such as MMP-1, -3 and -13 as well as ADAMTS-4 and -5.4
Target Actions Organism UBrain-derived neurotrophic factor Not Available Humans UGlial cell line-derived neurotrophic factor Not Available Humans UVascular endothelial growth factor A, long form Not Available Humans UC-C motif chemokine 2 Not Available Humans - Absorption
Chondroitin sulfate is absorbed from the gastrointestinal tract.2 The absorbed portion reaches a ratio of 10% as unchanged chondroitin sulfate and 90% as depolymerized low-molecular-weight derivatives. This absorption depends on the sulfation status. The bioavailability of chondroitin sulfate ranges from 10-20% following oral administration. Reports have shown a consistent accumulation of the compound in joint tissue. The steady-state is attained after 3-4 days and it takes around 3-6 months to obtain the maximal effect.4
After intramuscular administration of chondroitin sulfate, the peak plasma level of 3.8 mcg/ml was reached after 90 min. When given orally, the peak plasma concentration of 4.6 mcg/ml was reached after 240 min.5
- Volume of distribution
After intramuscular administration of chondroitin sulfate, the apparent volume of distribution was 0.40 ml/g. When administered orally, the apparent volume of distribution changed to 0.44ml/g.5
- Protein binding
Chondroitin sulfate protein binding reports have shown a very low percentage of protein binding of only 0.23% of the total protein.6
- Metabolism
Chondroitin sulfate is not metabolized by cytochrome P450.4 Reports have indicated the presence in plasma of mono-, oligo- and polysaccharides with a molecular weight of less of 5 kDa which are derived from the partial digestion of exogenous chondroitin sulfate.5 The reported degradation of chondroitin sulfate seems to be very complex and led by the formation of smaller digestion derivatives of the original form.9
Hover over products below to view reaction partners
- Route of elimination
Chondroitin sulfate is excreted in the urine as intact polymers and as partial degradation products.2 After intramuscular administration, about 37% of the administered dose is excreted by urine during the first 24 hours as high- and low-molecular-weight derivatives.5
- Half-life
The approximate half-life of chondroitin sulfate and its derivative metabolites is 15 hours.4 After intramuscular administration of chondroitin sulfate in humans, the elimination half-life of the chondroitin sulfate was of 275 min. When administered orally, the elimination half-life was presented at 310 min.5
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Chondroitin sulfate does not present a carcinogenic potential.7 On tolerability assays, it has been shown to present great safety and good tolerability without significant severe side effects.4
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbacavir Abacavir may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level. Aceclofenac Aceclofenac may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level. Acemetacin Acemetacin may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level. Acenocoumarol Chondroitin sulfate may increase the anticoagulant activities of Acenocoumarol. Acetazolamide Acetazolamide may increase the excretion rate of Chondroitin sulfate which could result in a lower serum level and potentially a reduction in efficacy. - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Chondroitin sulfate (bovine) 6IC1M3OG5Z 9007-28-7 Not applicable Chondroitin sulfate (chicken) 7VZ9466BAB Not Available Not applicable Chondroitin sulfate (porcine) V5E8ELO4W9 Not Available Not applicable Chondroitin sulfate (shark) 2ZAJ1K50XH Not Available Not applicable Chondroitin sulfate sodium (bovine) 8QTV3DTT8W 39455-18-0 Not applicable Chondroitin sulfate sodium (chicken) 4T078B3Z6V Not Available Not applicable Chondroitin sulfate sodium (porcine) R27OH35FYQ Not Available Not applicable Chondroitin sulfate sodium (shark) Q75WVO004L Not Available Not applicable - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Chondroitin sulphate 500mg tablets Tablet 500 mg Oral BIO-LIFE MARKETING SDN. BHD. 2020-09-08 2020-12-17 Malaysia 
Condros capsule Capsule 400 mg Oral AV MANUFACTURING SDN.BHD 2017-05-05 2019-05-09 Malaysia CONSULF CAPSULES Capsule 400 mg Oral AV MANUFACTURING SDN.BHD 2013-12-26 2017-01-19 Malaysia Gold Life® BioFlex Chondroitin Sulphate Capsule 400mg Capsule 400 mg Oral MEDIPHARM INDUSTRIES SDN. BHD. 2020-09-08 Not applicable Malaysia Kordel"s Chondroitin 400mg Capsule 400 mg Oral CAMBERT(M) SDN. BHD. 2020-09-08 2024-02-24 Malaysia - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Adaxil Chondroitin sulfate sodium (bovine) (600 mg) + Glucosamine sulfate (750 mg) Powder Oral MYLAN HEALTHCARE SDN. BHD. 2020-09-08 Not applicable Malaysia Appeton Essentials Glucosamine 500 + Chondroitin 400 Tablet Chondroitin sulfate sodium (bovine) (400 mg) + Glucosamine sulfate potassium chloride (500 mg) Tablet Oral KOTRA PHARMA (M) SDN. BHD. 2020-09-08 Not applicable Malaysia Arthro Capsule Chondroitin sulfate sodium (bovine) (200 mg) + Glucosamine sulfate (375 mg) Capsule Oral STERILINE SDN. BHD. 2019-05-23 2023-07-10 Malaysia ARTHRO-S Powder for Oral Solution Chondroitin sulfate sodium (bovine) (1200 mg) + Glucosamine sulfate potassium chloride (1500 mg) Powder Oral Noripharma Sdn. Bhd. 2020-09-08 Not applicable Malaysia ARTROFORT(R) COMPLEX Chondroitin sulfate (bovine) (600 mg) + Glucosamine (750 mg) Powder Oral บริษัท เมด้า ฟาม่าร์ (ประเทศไทย) จำกัด 2011-11-04 Not applicable Thailand 
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Medi-flexx Rx Joint Support Formula Chondroitin sulfate (chicken) (400 mg/1) + Dimethyl sulfone (200 mg/1) + Glucosamine sulfate (500 mg/1) Tablet Oral Two Hip Consulting, Llc 2014-12-05 2016-04-11 US 
Remaxazon External Patch Chondroitin sulfate sodium (bovine) (3 g/100g) + Capsaicin (.0285 g/100g) + Glucosamine (5 g/100g) + Lidocaine (4 g/100g) Patch Topical Home Aide Diganostics, Inc. 2015-03-09 Not applicable US
Categories
- ATC Codes
- M01AX25 — Chondroitin sulfate
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- Not Available
- CAS number
- 24967-93-9
- InChI Key
- Not Available
- InChI
- Not Available
- IUPAC Name
- Not Available
- SMILES
- Not Available
References
- General References
- Monfort J, Pelletier JP, Garcia-Giralt N, Martel-Pelletier J: Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues. Ann Rheum Dis. 2008 Jun;67(6):735-40. Epub 2007 Jul 20. [Article]
- da Cunha AL, de Oliveira LG, Maia LF, de Oliveira LF, Michelacci YM, de Aguiar JA: Pharmaceutical grade chondroitin sulfate: Structural analysis and identification of contaminants in different commercial preparations. Carbohydr Polym. 2015 Dec 10;134:300-8. doi: 10.1016/j.carbpol.2015.08.006. Epub 2015 Aug 8. [Article]
- Volpi N: Quality of different chondroitin sulfate preparations in relation to their therapeutic activity. J Pharm Pharmacol. 2009 Oct;61(10):1271-80. doi: 10.1211/jpp/61.10.0002. [Article]
- Henrotin Y, Mathy M, Sanchez C, Lambert C: Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48. doi: 10.1177/1759720X10383076. [Article]
- Ronca G, Conte A: Metabolic fate of partially depolymerized shark chondroitin sulfate in man. Int J Clin Pharmacol Res. 1993;13 Suppl:27-34. [Article]
- Saito A, Munakata H: Analysis of plasma proteins that bind to glycosaminoglycans. Biochim Biophys Acta. 2007 Feb;1770(2):241-6. doi: 10.1016/j.bbagen.2006.10.015. Epub 2006 Nov 7. [Article]
- Chemical selection summary [Link]
- Arthritis foundation [Link]
- Metafishnet [Link]
- External Links
- KEGG Drug
- D00080
- KEGG Compound
- C00607
- PubChem Substance
- 347910430
- 2473
- Wikipedia
- Chondroitin_sulfate
- MSDS
- Download (143 KB)
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Completed Treatment Interstitial Cystitis 1 somestatus stop reason just information to hide Not Available Completed Treatment Macula Edema 1 somestatus stop reason just information to hide Not Available Recruiting Other Joint Pain 1 somestatus stop reason just information to hide Not Available Terminated Treatment Interstitial Cystitis 1 somestatus stop reason just information to hide 4 Completed Prevention Recurrent Cystitis 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral Capsule Oral 400 mg Tablet Oral 500 mg Granule, for solution Oral 800 MG Powder, for solution Oral Capsule Oral Granule, for solution Oral Tablet Oral 800.000 mg Tablet Oral 800 mg Gel Oral 1200 MG Powder, for suspension Oral Tablet, coated Oral Capsule, liquid filled Oral Powder, for solution Oral 1200 mg Powder Oral 1200.000 mg Granule Oral Capsule, coated Oral Gel Topical 0.445 % Cream Topical 40 g Capsule Oral 150 MG Capsule Oral 300 MG Solution Oral Tablet, effervescent Oral Powder Oral Tablet, film coated Granule, for solution Oral 400 MG Injection, solution Intramuscular 100 MG/4ML Tablet Oral Solution Ophthalmic 1.0000 mg Tablet Oral 400 mg Tablet, delayed release Oral Tablet, film coated Oral Powder Oral 1500.000 mg Patch Topical Solution Ophthalmic Solution Ophthalmic; Topical Capsule Oral 500 mg Capsule Oral 600 mg Capsule Oral 500 mg/1 Capsule Oral 400.00 mg Tablet Oral 300.000 mg Capsule Cream Topical Capsule Oral 450 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 190-194ºC Lipowitz A. and Newton C. Degenerative joint disease and traumatic arthritis. water solubility Soluble 'MSDS' pKa 1.5-2 Chandran P. and Horkay F. (2012). Acta Biomater. - Predicted Properties
- Not Available
- Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Targets
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability
- Specific Function
- growth factor activity
- Gene Name
- BDNF
- Uniprot ID
- P23560
- Uniprot Name
- Brain-derived neurotrophic factor
- Molecular Weight
- 27817.72 Da
References
- Nandini CD, Mikami T, Ohta M, Itoh N, Akiyama-Nambu F, Sugahara K: Structural and functional characterization of oversulfated chondroitin sulfate/dermatan sulfate hybrid chains from the notochord of hagfish. Neuritogenic and binding activities for growth factors and neurotrophic factors. J Biol Chem. 2004 Dec 3;279(49):50799-809. Epub 2004 Sep 22. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:8493557). Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor (PubMed:10829012, PubMed:25242331, PubMed:31535977). Involved in the development of the neural crest (PubMed:15242795)
- Specific Function
- chemoattractant activity involved in axon guidance
- Gene Name
- GDNF
- Uniprot ID
- P39905
- Uniprot Name
- Glial cell line-derived neurotrophic factor
- Molecular Weight
- 23719.85 Da
References
- Nandini CD, Mikami T, Ohta M, Itoh N, Akiyama-Nambu F, Sugahara K: Structural and functional characterization of oversulfated chondroitin sulfate/dermatan sulfate hybrid chains from the notochord of hagfish. Neuritogenic and binding activities for growth factors and neurotrophic factors. J Biol Chem. 2004 Dec 3;279(49):50799-809. Epub 2004 Sep 22. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia-mediated cell death (By similarity)
- Specific Function
- chemoattractant activity
- Gene Name
- VEGFA
- Uniprot ID
- P15692
- Uniprot Name
- Vascular endothelial growth factor A, long form
- Molecular Weight
- 43596.94 Da
References
- Nandini CD, Mikami T, Ohta M, Itoh N, Akiyama-Nambu F, Sugahara K: Structural and functional characterization of oversulfated chondroitin sulfate/dermatan sulfate hybrid chains from the notochord of hagfish. Neuritogenic and binding activities for growth factors and neurotrophic factors. J Biol Chem. 2004 Dec 3;279(49):50799-809. Epub 2004 Sep 22. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:10529171, PubMed:10587439, PubMed:9837883). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:10587439, PubMed:9837883). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8195247, PubMed:8627182, PubMed:9792674). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690)
- Specific Function
- CCR chemokine receptor binding
- Gene Name
- CCL2
- Uniprot ID
- P13500
- Uniprot Name
- C-C motif chemokine 2
- Molecular Weight
- 11024.87 Da
References
- Distler JH, Jungel A, Caretto D, Schulze-Horsel U, Kowal-Bielecka O, Gay RE, Michel BA, Muller-Ladner U, Kalden JR, Gay S, Distler O: Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells. Arthritis Rheum. 2006 Jan;54(1):214-25. [Article]
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Plays an important role in the degradation of dermatan and keratan sulfates
- Specific Function
- beta-glucuronidase activity
- Gene Name
- GUSB
- Uniprot ID
- P08236
- Uniprot Name
- Beta-glucuronidase
- Molecular Weight
- 74731.46 Da
References
- Metafishnet [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:8123671, PubMed:8672428, PubMed:9694901). The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436). Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:8123671, PubMed:8672428, PubMed:9694901). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity)
- Specific Function
- acetylglucosaminyltransferase activity
- Gene Name
- HEXB
- Uniprot ID
- P07686
- Uniprot Name
- Beta-hexosaminidase subunit beta
- Molecular Weight
- 63136.825 Da
References
- Metafishnet [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate
- Specific Function
- calcium ion binding
- Gene Name
- IDS
- Uniprot ID
- P22304
- Uniprot Name
- Iduronate 2-sulfatase
- Molecular Weight
- 61872.405 Da
References
- Metafishnet [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity)
- Specific Function
- arylsulfatase activity
- Gene Name
- ARSB
- Uniprot ID
- P15848
- Uniprot Name
- Arylsulfatase B
- Molecular Weight
- 59686.71 Da
References
- Metafishnet [Link]
Drug created at November 11, 2015 19:54 / Updated at February 13, 2021 11:02