Excitatory amino acid transporter 2

BE0000884ProteinHumansSLC1A2

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:15265858, PubMed:26690923, PubMed:7521911). It is acted on by 4 drugs in DrugBank.

Gene name
SLC1A2
UniProtKB entry
P43004Swiss-Prot
Cellular location
Cell membrane
Residues / weight
574 residues · 62,104 Da
Also known as
EAAT2 · GLT1 · Glutamate/aspartate transporter II · Sodium-dependent glutamate/aspartate transporter 2 · Solute carrier family 1 member 2

Resolves to

Protein
UniProtP43004UniProt nameEAA2_HUMAN
Gene
HGNCHGNC:10940NCBI Gene6506GenBank487341GeneCardsSLC1A2
Pharmacology
IUPHAR/GtoPdb869KEGGhsa:6506
Structure
PDB7VR7PDB7VR8PDB7XR4
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Excitatory amino acid transporter 2, how selective are they, and which programs against it are still in active trials?

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