Glutathione hydrolase 1 proenzyme

BE0000889ProteinHumansGGT1

Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4) (PubMed:17924658, PubMed:21447318, PubMed:27791009). It is acted on by 5 drugs in DrugBank.

Gene name
GGT1
UniProtKB entry
P19440Swiss-Prot
Cellular location
Cell membrane
Residues / weight
569 residues · 61,410 Da
Also known as
3.4.19.13 · Gamma-glutamyltransferase 1 · Gamma-glutamyltranspeptidase 1 · GGT · GGT 1

Resolves to

Protein
UniProtP19440UniProt nameGGT1_HUMAN
Gene
HGNCHGNC:4250NCBI Gene2678GenBank183138GeneCardsGGT1
Pharmacology
KEGGhsa:2678
Structure
PDB4GDXPDB4GG2PDB4Z9O
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutathione hydrolase 1 proenzyme, how selective are they, and which programs against it are still in active trials?

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