Cartilage oligomeric matrix protein

BE0000899ProteinHumansCOMP

Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. It is acted on by 1 drug in DrugBank.

Gene name
COMP
UniProtKB entry
P49747Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix
Residues / weight
757 residues · 82,860 Da
Also known as
COMP · Thrombospondin-5 · TSP5

Resolves to

Protein
UniProtP49747UniProt nameCOMP_HUMAN
Gene
HGNCHGNC:2227NCBI Gene1311GenBank602450GeneCardsCOMP
Pharmacology
KEGGhsa:1311
Structure
PDB3FBY
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cartilage oligomeric matrix protein, how selective are they, and which programs against it are still in active trials?

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