Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

BE0000906ProteinHumansPCK1

Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis (PubMed:24863970, PubMed:26971250, PubMed:28216384, PubMed:30193097). It is acted on by 5 drugs in DrugBank.

Gene name
PCK1
UniProtKB entry
P35558Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
622 residues · 69,194 Da
Also known as
4.1.1.32 · PEPCK-C · PEPCK1 · Serine-protein kinase PCK1

Resolves to

Protein
UniProtP35558UniProt namePCKGC_HUMAN
Gene
HGNCHGNC:8724NCBI Gene5105GenBank189945GeneCardsPCK1
Pharmacology
KEGGhsa:5105
Structure
PDB1KHBPDB1KHEPDB1KHF
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
13GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
22+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Phosphoenolpyruvate carboxykinase, cytosolic [GTP], and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In