Cytosolic 10-formyltetrahydrofolate dehydrogenase

BE0000933ProteinHumansALDH1L1

Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:19933275, PubMed:21238436). It is acted on by 1 drug in DrugBank.

Gene name
ALDH1L1
UniProtKB entry
O75891Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
902 residues · 98,829 Da
Also known as
1.5.1.6 · 10-FTHFDH · Aldehyde dehydrogenase family 1 member L1 · FDH · FTHFD

Resolves to

Protein
UniProtO75891UniProt nameAL1L1_HUMAN
Gene
HGNCHGNC:3978NCBI Gene10840GenBank3560541GeneCardsALDH1L1
Pharmacology
KEGGhsa:10840
Structure
PDB2BW0PDB2CFIPDB2CQ8
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Cytosolic 10-formyltetrahydrofolate dehydrogenase, and which indications are they being tested in?

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