Interferon gamma

BE0000944ProteinHumansIFNG

Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:16914093, PubMed:8666937). It is acted on by 9 drugs in DrugBank.

Gene name
IFNG
UniProtKB entry
P01579Swiss-Prot
Cellular location
Secreted
Residues / weight
166 residues · 19,348 Da
Also known as
IFN-gamma · Immune interferon

Resolves to

Protein
UniProtP01579UniProt nameIFNG_HUMAN
Gene
HGNCHGNC:5438NCBI Gene3458GenBank32692GeneCardsIFNG
Pharmacology
KEGGhsa:3458
Structure
PDB1EKUPDB1FG9PDB1FYH
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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104Clinical trialsTrials of drugs acting on it, by phase and status
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34GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interferon gamma, how selective are they, and which programs against it are still in active trials?

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