Thiamine transporter 2

BE0000963ProteinHumansSLC19A3

Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism (PubMed:11731220, PubMed:33008889, PubMed:35512554, PubMed:35724964). It is acted on by 3 drugs in DrugBank.

Gene name
SLC19A3
UniProtKB entry
Q9BZV2Swiss-Prot
Cellular location
Membrane
Residues / weight
496 residues · 55,664 Da
Also known as
Solute carrier family 19 member 3 · ThTr-2 · ThTr2

Resolves to

Protein
UniProtQ9BZV2UniProt nameS19A3_HUMAN
Gene
HGNCHGNC:16266NCBI Gene80704GenBank12483888GeneCardsSLC19A3
Pharmacology
KEGGhsa:80704
Structure
PDB8S4UPDB8S5UPDB8S5W
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thiamine transporter 2, how selective are they, and which programs against it are still in active trials?

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