Apoptosis-inducing factor 1, mitochondrial

BE0000965ProteinHumansAIFM1

Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). It is acted on by 2 drugs in DrugBank.

Gene name
AIFM1
UniProtKB entry
O95831Swiss-Prot
Cellular location
Mitochondrion intermembrane space
Residues / weight
613 residues · 66,900 Da
Also known as
1.6.99.- · AIF · PDCD8 · Programmed cell death protein 8

Resolves to

Protein
UniProtO95831UniProt nameAIFM1_HUMAN
Gene
HGNCHGNC:8768NCBI Gene9131GenBank4323587GeneCardsAIFM1
Pharmacology
KEGGhsa:9131
Structure
PDB1M6IPDB4BURPDB4BV6
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Apoptosis-inducing factor 1, mitochondrial, how selective are they, and which programs against it are still in active trials?

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