Inositol monophosphatase 2

BE0000983ProteinHumansIMPA2

Phosphatase that can use myo-inositol monophosphates, myo-inositol 1,4-diphosphate, scyllo-inositol-1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate and 2'-AMP as substrates in vitro (PubMed:17068342). It is acted on by 4 drugs in DrugBank.

Gene name
IMPA2
UniProtKB entry
O14732Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
288 residues · 31,321 Da
Also known as
3.1.3.25 · IMP 2 · IMP.18P · IMPase 2 · Inositol-1(or 4)-monophosphatase 2

Resolves to

Protein
UniProtO14732UniProt nameIMPA2_HUMAN
Gene
HGNCHGNC:6051NCBI Gene3613GenBank2406666GeneCardsIMPA2
Pharmacology
KEGGhsa:3613
Structure
PDB2CZHPDB2CZIPDB2CZK
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inositol monophosphatase 2, how selective are they, and which programs against it are still in active trials?

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