Long-chain-fatty-acid--CoA ligase 4

BE0000996ProteinHumansACSL4

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233, PubMed:31061331, PubMed:38720107). It is acted on by 4 drugs in DrugBank.

Gene name
ACSL4
UniProtKB entry
O60488Swiss-Prot
Cellular location
Mitochondrion outer membrane
Residues / weight
711 residues · 79,187 Da
Also known as
6.2.1.3 · ACS4 · Arachidonate--CoA ligase · FACL4 · LACS 4

Resolves to

Protein
UniProtO60488UniProt nameACSL4_HUMAN
Gene
HGNCHGNC:3571NCBI Gene2182GenBank3158351GeneCardsACSL4
Pharmacology
KEGGhsa:2182
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Long-chain-fatty-acid--CoA ligase 4, how selective are they, and which programs against it are still in active trials?

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