Interleukin-3 receptor subunit alpha

BE0001036ProteinHumansIL3RA

Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:10527461). It is acted on by 11 drugs in DrugBank.

Gene name
IL3RA
UniProtKB entry
P26951Swiss-Prot
Cellular location
Cell membrane
Residues / weight
378 residues · 43,330 Da
Also known as
IL-3 receptor subunit alpha · IL-3R subunit alpha · IL-3R-alpha · IL-3RA · IL3R

Resolves to

Protein
UniProtP26951UniProt nameIL3RA_HUMAN
Gene
HGNCHGNC:6012NCBI Gene3563GenBank186331GeneCardsIL3RA
Pharmacology
KEGGhsa:3563
Structure
PDB4JZJPDB5UV8PDB5UWC
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
6Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
3GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
36+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Interleukin-3 receptor subunit alpha, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In