Muplestim

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Muplestim
DrugBank Accession Number
DB12431
Background

Muplestim is under investigation in clinical trial NCT00002258 (A Phase I, Open Label Trial to Evaluate the Safety, Tolerance and Biological Effects of SDZ ILE-964 (Recombinant Human Interleukin-3, RhIL-3) in HIV Infected Patients With Cytopenia).

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Other protein based therapies
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • Human interleukin-3 (nonglycosylated)
  • Interleukin 3
  • Interleukin 3 (human)
  • Interleukin-3
  • Interleukin-3 human (recombinant)
  • Multipotential colony-stimulating factor
  • Muplestim
External IDs
  • Interleukin 3

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
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Avoid life-threatening adverse drug events & improve clinical decision support.
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
CyclophosphamideThe risk or severity of pulmonary toxicity can be increased when Muplestim is combined with Cyclophosphamide.
VinblastineThe risk or severity of peripheral neuropathy can be increased when Muplestim is combined with Vinblastine.
VincristineThe risk or severity of peripheral neuropathy can be increased when Muplestim is combined with Vincristine.
VindesineThe risk or severity of peripheral neuropathy can be increased when Muplestim is combined with Vindesine.
VinflunineThe risk or severity of peripheral neuropathy can be increased when Muplestim is combined with Vinflunine.
VinorelbineThe risk or severity of peripheral neuropathy can be increased when Muplestim is combined with Vinorelbine.
Interactions
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Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
A802907MI4
CAS number
148641-02-5

References

General References
Not Available
PubChem Substance
347911334
RxNav
1311225

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2RecruitingTreatmentBlastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)2
1CompletedTreatmentCytopenias / Human Immunodeficiency Virus (HIV) Infections1
1TerminatedSupportive CareMalignant Lymphomas / Neutropenia1
1, 2CompletedTreatmentBreast Cancer / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic/Myeloproliferative Diseases1
1, 2Not Yet RecruitingTreatmentLymphoblastic lymphoma (Precursor T-lymphoblastic lymphoma/leukemia) refractory / Recurrent Adult Lymphoblastic Lymphoma / Recurrent B Acute Lymphoblastic Leukemia / Recurrent T Acute Lymphoblastic Leukemia / Refractory B Acute Lymphoblastic Leukemia / Refractory T Acute Lymphoblastic Leukemia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on October 20, 2016 22:22 / Updated on February 21, 2021 18:53