Excitatory amino acid transporter 3

BE0001054ProteinHumansSLC1A1

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:21123949, PubMed:26690923, PubMed:33658209, PubMed:7521911, PubMed:7914198, PubMed:8857541). It is acted on by 4 drugs in DrugBank.

Gene name
SLC1A1
UniProtKB entry
P43005Swiss-Prot
Cellular location
Cell membrane
Residues / weight
524 residues · 57,100 Da
Also known as
EAAC1 · EAAT3 · Excitatory amino-acid carrier 1 · HEAAC1 · Neuronal and epithelial glutamate transporter

Resolves to

Protein
UniProtP43005UniProt nameEAA3_HUMAN
Gene
HGNCHGNC:10939NCBI Gene6505GenBank507898GeneCardsSLC1A1
Pharmacology
IUPHAR/GtoPdb870KEGGhsa:6505
Structure
PDB6S3QPDB6X2LPDB6X2Z
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Excitatory amino acid transporter 3, how selective are they, and which programs against it are still in active trials?

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