Mitogen-activated protein kinase 3

BE0001062ProteinHumansMAPK3

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:34497368). It is acted on by 9 drugs in DrugBank.

Gene name
MAPK3
UniProtKB entry
P27361Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
379 residues · 43,135 Da
Also known as
2.7.11.24 · ERK-1 · ERK1 · ERT2 · Extracellular signal-regulated kinase 1

Resolves to

Protein
UniProtP27361UniProt nameMK03_HUMAN
Gene
HGNCHGNC:6877NCBI Gene5595GenBank31221GeneCardsMAPK3
Pharmacology
IUPHAR/GtoPdb1494KEGGhsa:5595
Structure
PDB2ZOQPDB4QTBPDB6GES
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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10Clinical trialsTrials of drugs acting on it, by phase and status
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24GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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69+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase 3, how selective are they, and which programs against it are still in active trials?

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