E3 ubiquitin-protein ligase TRIM13

BE0001063ProteinHumansTRIM13

Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). It is acted on by 3 drugs in DrugBank.

Gene name
TRIM13
UniProtKB entry
O60858Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
407 residues · 46,987 Da
Also known as
2.3.2.27 · B-cell chronic lymphocytic leukemia tumor suppressor Leu5 · LEU5 · Leukemia-associated protein 5 · Putative tumor suppressor RFP2

Resolves to

Protein
UniProtO60858UniProt nameTRI13_HUMAN
Gene
HGNCHGNC:9976NCBI Gene10206GenBank3133092GeneCardsTRIM13
Pharmacology
KEGGhsa:10206
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which compounds in development act on E3 ubiquitin-protein ligase TRIM13, and which indications are they being tested in?

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