Somatostatin
Details
- Name
- Somatostatin
- Kind
- protein
- Synonyms
- Growth hormone release-inhibiting factor
- Gene Name
- SST
- UniProtKB Entry
- P61278Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0010750|Somatostatin MLSCRLQCALAALSIVLALGCVTGAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEP NQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC
- Number of residues
- 116
- Molecular Weight
- 12735.395
- Theoretical pI
- 5.18
- GO Classification
- Processeschemical synaptic transmission / G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / regulation of postsynaptic membrane neurotransmitter receptor levels / response to organonitrogen compound / response to xenobiotic stimulus / somatostatin signaling pathwayComponentsGABA-ergic synapse / neuronal dense core vesicle
- General Function
- Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin
- Specific Function
- Hormone activity
- Pfam Domain Function
- Somatostatin (PF03002)
- Signal Regions
- 1-24
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0010751|Somatostatin (SST) ATGCTGTCCTGCCGCCTCCAGTGCGCGCTGGCTGCGCTGTCCATCGTCCTGGCCCTGGGC TGTGTCACCGGCGCTCCCTCGGACCCCAGACTCCGTCAGTTTCTGCAGAAGTCCCTGGCT GCTGCCGCGGGGAAGCAGGAACTGGCCAAGTACTTCTTGGCAGAGCTGCTGTCTGAACCC AACCAGACGGAGAATGATGCCCTGGAACCTGAAGATCTGTCCCAGGCTGCTGAGCAGGAT GAAATGAGGCTTGAGCTGCAGAGATCTGCTAACTCAAACCCGGCTATGGCACCCCGAGAA CGCAAAGCTGGCTGCAAGAATTTCTTCTGGAAGACTTTCACATCCTGTTAG
- Chromosome Location
- 3
- Locus
- 3q27.3
- External Identifiers
Resource Link UniProtKB ID P61278 UniProtKB Entry Name SMS_HUMAN GenBank Protein ID 338288 GenBank Gene ID J00306 GeneCard ID SST GenAtlas ID SST HGNC ID HGNC:11329 PDB ID(s) 2MI1, 7T10, 7WIC, 7WJ5, 7XAT, 7XMR, 7XMS, 7Y27 KEGG ID hsa:6750 NCBI Gene ID 6750 - General References
- Shen LP, Pictet RL, Rutter WJ: Human somatostatin I: sequence of the cDNA. Proc Natl Acad Sci U S A. 1982 Aug;79(15):4575-9. [Article]
- Shen LP, Rutter WJ: Sequence of the human somatostatin I gene. Science. 1984 Apr 13;224(4645):168-71. [Article]
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- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Cysteamine approved, investigational yes target binder Details