Protein-arginine deiminase type-4

BE0001092ProteinHumansPADI4

Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:19153223, PubMed:21245532, PubMed:25622091). It is acted on by 6 drugs in DrugBank.

Gene name
PADI4
UniProtKB entry
Q9UM07Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
663 residues · 74,079 Da
Also known as
3.5.3.15 · HL-60 PAD · PAD4 · PADI5 · PDI5

Resolves to

Protein
UniProtQ9UM07UniProt namePADI4_HUMAN
Gene
HGNCHGNC:18368NCBI Gene23569GenBank5913971GeneCardsPADI4
Pharmacology
IUPHAR/GtoPdb2877KEGGhsa:23569
Structure
PDB1WD8PDB1WD9PDB1WDA
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein-arginine deiminase type-4, how selective are they, and which programs against it are still in active trials?

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