CD44 antigen

BE0001113ProteinHumansCD44

Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). It is acted on by 2 drugs in DrugBank.

Gene name
CD44
UniProtKB entry
P16070Swiss-Prot
Cellular location
Cell membrane
Residues / weight
742 residues · 81,537 Da
Also known as
CDw44 · ECMR-III · Epican · Extracellular matrix receptor III · GP90 lymphocyte homing/adhesion receptor

Resolves to

Protein
UniProtP16070UniProt nameCD44_HUMAN
Gene
HGNCHGNC:1681NCBI Gene960GenBank180197GeneCardsCD44
Pharmacology
KEGGhsa:960
Structure
PDB1POZPDB1UUHPDB2I83
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9Clinical trialsTrials of drugs acting on it, by phase and status
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20GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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47+ReferencesStructured and connected to the statements they support
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Which approved drugs act on CD44 antigen, how selective are they, and which programs against it are still in active trials?

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