Excitatory amino acid transporter 1

BE0001115ProteinHumansSLC1A3

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515, PubMed:7521911, PubMed:8123008). It is acted on by 4 drugs in DrugBank.

Gene name
SLC1A3
UniProtKB entry
P43003Swiss-Prot
Cellular location
Cell membrane
Residues / weight
542 residues · 59,572 Da
Also known as
EAAT1 · GLAST · GLAST-1 · GLAST1 · Sodium-dependent glutamate/aspartate transporter 1

Resolves to

Protein
UniProtP43003UniProt nameEAA1_HUMAN
Gene
HGNCHGNC:10941NCBI Gene6507GeneCardsSLC1A3
Pharmacology
IUPHAR/GtoPdb868KEGGhsa:6507
Structure
PDB5LLMPDB5LLUPDB5LM4
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Excitatory amino acid transporter 1, how selective are they, and which programs against it are still in active trials?

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