Leukotriene C4 synthase

BE0001117ProteinHumansLTC4S

Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:23409838, PubMed:27365393, PubMed:27791009, PubMed:7937884, PubMed:9153254). It is acted on by 2 drugs in DrugBank.

Gene name
LTC4S
UniProtKB entry
Q16873Swiss-Prot
Cellular location
Nucleus outer membrane
Residues / weight
150 residues · 16,566 Da
Also known as
4.4.1.20 · Glutathione S-transferase LTC4 · Leukotriene-C(4) synthase · Leukotriene-C4 synthase · LTC4 synthase

Resolves to

Protein
UniProtQ16873UniProt nameLTC4S_HUMAN
Gene
HGNCHGNC:6719NCBI Gene4056GenBank520485GeneCardsLTC4S
Pharmacology
IUPHAR/GtoPdb1391KEGGhsa:4056
Structure
PDB2PNOPDB2UUHPDB2UUI
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Leukotriene C4 synthase, how selective are they, and which programs against it are still in active trials?

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